CLCN4
Gene Information
- Official Symbol: CLCN4
- Official Name: chloride voltage-gated channel 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 1183
- UniProt: P51793
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012].
- UniProt Summary: Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. {ECO:0000269|PubMed:23647072, ECO:0000269|PubMed:25644381}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8268
- Expression level (log2 read counts): -1.4
CLCN4 Expression in NALM6 Cells: -1.4
