CLIC2 [The Human Chemical-Genetic Interaction Map Project]

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======= CLIC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLIC2
  * **<color #00a2e8>Official Name</color>**: chloride intracellular channel 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1193|1193]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15247|O15247]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLIC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLIC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300138|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a chloride intracellular channel protein. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. This protein plays a role in inhibiting the function of ryanodine receptor 2. A mutation in this gene is the cause of an X-linked form of cognitive disability. [provided by RefSeq, Jul 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. {ECO:0000269|PubMed:15147738, ECO:0000269|PubMed:15916532, ECO:0000269|PubMed:17945253}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of ryanodine-sensitive calcium-release channel activity|
|negative regulation of release of sequestered calcium ion into cytosol|
|positive regulation of sequestering of calcium ion|
|negative regulation of calcium ion transport into cytosol|
|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|
|glutathione peroxidase activity|
|regulation of cardiac muscle contraction by calcium ion signaling|
|regulation of ryanodine-sensitive calcium-release channel activity|
|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|glutathione transferase activity|
|negative regulation of calcium-mediated signaling|
|negative regulation of calcium ion transmembrane transporter activity|
|negative regulation of calcium ion transmembrane transport|
|negative regulation of cation channel activity|
|voltage-gated ion channel activity|
|chloride channel complex|
|chloride channel activity|
|negative regulation of calcium ion transport|
|negative regulation of ion transmembrane transporter activity|
|regulation of cardiac muscle contraction|
|regulation of release of sequestered calcium ion into cytosol|
|negative regulation of transporter activity|
|negative regulation of cation transmembrane transport|
|regulation of calcium ion transmembrane transporter activity|
|intracellular|
|chloride transmembrane transport|
|regulation of striated muscle contraction|
|cellular oxidant detoxification|
|negative regulation of ion transmembrane transport|
|regulation of calcium-mediated signaling|
|regulation of calcium ion transport into cytosol|
|cellular detoxification|
|chloride transport|
|inorganic anion transmembrane transport|
|negative regulation of transmembrane transport|
|regulation of sequestering of calcium ion|
|detoxification|
|calcium-mediated signaling|
|negative regulation of ion transport|
|regulation of calcium ion transmembrane transport|
|inorganic anion transport|
|regulation of muscle contraction|
|regulation of cation channel activity|
|positive regulation of binding|
|cellular response to toxic substance|
|regulation of muscle system process|
|regulation of heart contraction|
|regulation of calcium ion transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|anion transmembrane transport|
|regulation of transporter activity|
|regulation of blood circulation|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|regulation of binding|
|regulation of metal ion transport|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|negative regulation of intracellular signal transduction|
|response to toxic substance|
|regulation of transmembrane transport|
|anion transport|
|regulation of system process|
|inorganic ion transmembrane transport|
|regulation of ion transport|
|regulation of cellular localization|
|ion transmembrane transport|
|negative regulation of molecular function|
|negative regulation of signal transduction|
|transmembrane transport|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|negative regulation of response to stimulus|
|intracellular signal transduction|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16136
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLIC2 Expression in NALM6 Cells: 0.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>