CLIC2

Gene Information

Official Symbol: CLIC2
Official Name: chloride intracellular channel 2
Aliases and Previous Symbols: N/A
Entrez ID: 1193
UniProt: O15247
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a chloride intracellular channel protein. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. This protein plays a role in inhibiting the function of ryanodine receptor 2. A mutation in this gene is the cause of an X-linked form of cognitive disability. [provided by RefSeq, Jul 2017].
UniProt Summary: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. {ECO:0000269|PubMed:15147738, ECO:0000269|PubMed:15916532, ECO:0000269|PubMed:17945253}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16136
Expression level (log2 read counts): 0.36

Expression Distribution

negative regulation of ryanodine-sensitive calcium-release channel activity
negative regulation of release of sequestered calcium ion into cytosol
positive regulation of sequestering of calcium ion
negative regulation of calcium ion transport into cytosol
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
glutathione peroxidase activity
regulation of cardiac muscle contraction by calcium ion signaling
regulation of ryanodine-sensitive calcium-release channel activity
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
glutathione transferase activity
negative regulation of calcium-mediated signaling
negative regulation of calcium ion transmembrane transporter activity
negative regulation of calcium ion transmembrane transport
negative regulation of cation channel activity
voltage-gated ion channel activity
chloride channel complex
chloride channel activity
negative regulation of calcium ion transport
negative regulation of ion transmembrane transporter activity
regulation of cardiac muscle contraction
regulation of release of sequestered calcium ion into cytosol
negative regulation of transporter activity
negative regulation of cation transmembrane transport
regulation of calcium ion transmembrane transporter activity
intracellular
chloride transmembrane transport
regulation of striated muscle contraction
cellular oxidant detoxification
negative regulation of ion transmembrane transport
regulation of calcium-mediated signaling
regulation of calcium ion transport into cytosol
cellular detoxification
chloride transport
inorganic anion transmembrane transport
negative regulation of transmembrane transport
regulation of sequestering of calcium ion
detoxification
calcium-mediated signaling
negative regulation of ion transport
regulation of calcium ion transmembrane transport