CLIP3

Gene Information

Official Symbol: CLIP3
Official Name: CAP-Gly domain containing linker protein 3
Aliases and Previous Symbols: N/A
Entrez ID: 25999
UniProt: Q96DZ5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes. {ECO:0000269|PubMed:19139280}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7172
Expression level (log2 read counts): 1.92

Expression Distribution

CAP GLY
Ank 2

ganglioside binding
chaperone-mediated protein transport
negative regulation of microtubule polymerization
peptidyl-L-cysteine S-palmitoylation
peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine
protein palmitoylation
Golgi stack
negative regulation of microtubule polymerization or depolymerization
peptidyl-cysteine modification
membrane biogenesis
positive regulation of glucose transmembrane transport
regulation of microtubule polymerization
positive regulation of protein localization to plasma membrane
regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of protein localization to cell periphery
negative regulation of protein polymerization
regulation of glucose transmembrane transport
regulation of microtubule polymerization or depolymerization
recycling endosome membrane
protein lipidation
lipoprotein biosynthetic process
trans-Golgi network membrane
regulation of protein localization to plasma membrane
positive regulation of endocytosis
fat cell differentiation
regulation of protein localization to cell periphery
lipoprotein metabolic process
positive regulation of protein localization to membrane
negative regulation of supramolecular fiber organization
negative regulation of protein complex assembly
negative regulation of cytoskeleton organization
early endosome membrane
regulation of cytokine-mediated signaling pathway
trans-Golgi network
regulation of response to cytokine stimulus
protein acylation
regulation of microtubule cytoskeleton organization
regulation of protein localization to membrane
positive regulation of transmembrane transport
regulation of endocytosis