CMKLR1

Gene Information

Official Symbol: CMKLR1
Official Name: chemerin chemokine-like receptor 1
Aliases and Previous Symbols: N/A
Entrez ID: 1240
UniProt: Q99788
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). {ECO:0000269|PubMed:15728234, ECO:0000269|PubMed:15753205, ECO:0000269|PubMed:20044979, ECO:0000269|PubMed:9603476}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5565
Expression level (log2 read counts): -0.33

Expression Distribution

complement receptor mediated signaling pathway
positive regulation of macrophage chemotaxis
negative regulation of interleukin-12 production
chemokine receptor activity
positive regulation of macrophage migration
regulation of macrophage chemotaxis
regulation of macrophage migration
regulation of granulocyte chemotaxis
regulation of mononuclear cell migration
regulation of interleukin-12 production
positive regulation of fat cell differentiation
chemokine-mediated signaling pathway
negative regulation of NF-kappaB transcription factor activity
positive regulation of leukocyte chemotaxis
response to chemokine
cellular response to chemokine
phospholipase C-activating G protein-coupled receptor signaling pathway
regulation of calcium-mediated signaling
positive regulation of cold-induced thermogenesis
regulation of leukocyte chemotaxis
regulation of fat cell differentiation
positive regulation of leukocyte migration
positive regulation of chemotaxis
regulation of cold-induced thermogenesis
negative regulation of DNA-binding transcription factor activity
regulation of leukocyte migration
signaling receptor activity
regulation of chemotaxis
negative regulation of cytokine production
positive regulation of cytosolic calcium ion concentration
regulation of cytosolic calcium ion concentration
regulation of DNA-binding transcription factor activity
cellular calcium ion homeostasis
immune response-activating cell surface receptor signaling pathway
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
immune response-regulating cell surface receptor signaling pathway
divalent inorganic cation homeostasis
skeletal system development
inflammatory response