CMPK1 [The Human Chemical-Genetic Interaction Map Project]

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======= CMPK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CMPK1
  * **<color #00a2e8>Official Name</color>**: cytidine/uridine monophosphate kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51727|51727]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30085|P30085]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CMPK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CMPK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191710|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000255|HAMAP-Rule:MF_03172, ECO:0000269|PubMed:10462544, ECO:0000269|PubMed:11912132, ECO:0000269|PubMed:23416111}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ADK|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|uridylate kinase activity|
|uridine kinase activity|
|cytidylate kinase activity|
|de novo pyrimidine nucleobase biosynthetic process|
|pyrimidine nucleobase biosynthetic process|
|UMP metabolic process|
|pyrimidine ribonucleoside monophosphate metabolic process|
|UMP biosynthetic process|
|pyrimidine ribonucleoside monophosphate biosynthetic process|
|nucleoside monophosphate phosphorylation|
|pyrimidine nucleoside monophosphate biosynthetic process|
|pyrimidine nucleoside monophosphate metabolic process|
|nucleoside diphosphate kinase activity|
|nucleobase biosynthetic process|
|pyrimidine nucleobase metabolic process|
|pyrimidine ribonucleotide biosynthetic process|
|pyrimidine ribonucleotide metabolic process|
|nucleobase-containing small molecule interconversion|
|ribonucleoside monophosphate biosynthetic process|
|nucleobase metabolic process|
|nucleoside monophosphate biosynthetic process|
|pyrimidine nucleotide biosynthetic process|
|ribonucleoside monophosphate metabolic process|
|pyrimidine-containing compound biosynthetic process|
|nucleoside diphosphate phosphorylation|
|nucleotide phosphorylation|
|pyrimidine nucleotide metabolic process|
|nucleoside triphosphate biosynthetic process|
|nucleoside monophosphate metabolic process|
|nucleoside diphosphate metabolic process|
|nucleoside triphosphate metabolic process|
|pyrimidine-containing compound metabolic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|ribonucleotide metabolic process|
|ribose phosphate metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|nucleolus|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.15|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.91|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 296/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|7/28|
|blood|9/28|
|bone|6/26|
|breast|11/33|
|central nervous system|10/56|
|cervix|2/4|
|colorectal|8/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|10/16|
|kidney|12/21|
|liver|11/20|
|lung|43/75|
|lymphocyte|6/16|
|ovary|5/26|
|pancreas|16/24|
|peripheral nervous system|6/16|
|plasma cell|9/15|
|prostate|0/1|
|skin|11/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|16/22|
|urinary tract|10/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2215
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CMPK1 Expression in NALM6 Cells: 6.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>