CMPK1

Gene Information

Official Symbol: CMPK1
Official Name: cytidine/uridine monophosphate kinase 1
Aliases and Previous Symbols: N/A
Entrez ID: 51727
UniProt: P30085
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000255|HAMAP-Rule:MF_03172, ECO:0000269|PubMed:10462544, ECO:0000269|PubMed:11912132, ECO:0000269|PubMed:23416111}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 296/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	7/28
blood	9/28
bone	6/26
breast	11/33
central nervous system	10/56
cervix	2/4
colorectal	8/17
esophagus	6/13
fibroblast	0/1
gastric	10/16
kidney	12/21
liver	11/20
lung	43/75
lymphocyte	6/16
ovary	5/26
pancreas	16/24
peripheral nervous system	6/16
plasma cell	9/15
prostate	0/1
skin	11/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	16/22
urinary tract	10/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 2215
Expression level (log2 read counts): 6.58

Expression Distribution

Screen	Score
AICAR 240μM R05 exp211	-2.15
UM0125461 0.74μM R02 exp84	-1.91
Talazoparib 0.006μM R06 exp299	-1.75

uridylate kinase activity
uridine kinase activity
cytidylate kinase activity
de novo pyrimidine nucleobase biosynthetic process
pyrimidine nucleobase biosynthetic process
UMP metabolic process
pyrimidine ribonucleoside monophosphate metabolic process
UMP biosynthetic process
pyrimidine ribonucleoside monophosphate biosynthetic process
nucleoside monophosphate phosphorylation
pyrimidine nucleoside monophosphate biosynthetic process
pyrimidine nucleoside monophosphate metabolic process
nucleoside diphosphate kinase activity
nucleobase biosynthetic process
pyrimidine nucleobase metabolic process
pyrimidine ribonucleotide biosynthetic process
pyrimidine ribonucleotide metabolic process
nucleobase-containing small molecule interconversion
ribonucleoside monophosphate biosynthetic process
nucleobase metabolic process
nucleoside monophosphate biosynthetic process
pyrimidine nucleotide biosynthetic process
ribonucleoside monophosphate metabolic process
pyrimidine-containing compound biosynthetic process
nucleoside diphosphate phosphorylation
nucleotide phosphorylation
pyrimidine nucleotide metabolic process
nucleoside triphosphate biosynthetic process
nucleoside monophosphate metabolic process
nucleoside diphosphate metabolic process
nucleoside triphosphate metabolic process
pyrimidine-containing compound metabolic process
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
ribonucleotide metabolic process
ribose phosphate metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process