CNR1 [The Human Chemical-Genetic Interaction Map Project]

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======= CNR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CNR1
  * **<color #00a2e8>Official Name</color>**: cannabinoid receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1268|1268]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21554|P21554]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CNR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CNR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114610|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srsx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retrograde trans-synaptic signaling by endocannabinoid|
|negative regulation of dopamine secretion|
|trans-synaptic signaling by lipid, modulating synaptic transmission|
|trans-synaptic signaling by endocannabinoid, modulating synaptic transmission|
|retrograde trans-synaptic signaling by lipid|
|cannabinoid receptor activity|
|positive regulation of presynaptic cytosolic calcium concentration|
|induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration|
|voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels|
|negative regulation of fatty acid beta-oxidation|
|cannabinoid signaling pathway|
|trans-synaptic signaling by lipid|
|trans-synaptic signaling by endocannabinoid|
|negative regulation of nitric-oxide synthase activity|
|positive regulation of fever generation|
|retrograde trans-synaptic signaling|
|regulation of penile erection|
|regulation of fever generation|
|positive regulation of acute inflammatory response to antigenic stimulus|
|negative regulation of action potential|
|positive regulation of synaptic vesicle exocytosis|
|integral component of mitochondrial membrane|
|negative regulation of fatty acid oxidation|
|negative regulation of monooxygenase activity|
|positive regulation of heat generation|
|positive regulation of inflammatory response to antigenic stimulus|
|trans-synaptic signaling, modulating synaptic transmission|
|regulation of heat generation|
|regulation of acute inflammatory response to antigenic stimulus|
|negative regulation of mast cell activation|
|presynaptic modulation of chemical synaptic transmission|
|negative regulation of catecholamine secretion|
|regulation of presynaptic cytosolic calcium ion concentration|
|regulation of fatty acid beta-oxidation|
|positive regulation of neurotransmitter secretion|
|neuron projection fasciculation|
|axonal fasciculation|
|negative regulation of lipid catabolic process|
|negative regulation of oxidoreductase activity|
|regulation of inflammatory response to antigenic stimulus|
|negative regulation of fatty acid metabolic process|
|negative regulation of amine transport|
|negative regulation of response to drug|
|regulation of feeding behavior|
|positive regulation of acute inflammatory response|
|regulation of fatty acid oxidation|
|regulation of synaptic transmission, GABAergic|
|response to morphine|
|response to isoquinoline alkaloid|
|neuron cellular homeostasis|
|positive regulation of blood pressure|
|positive regulation of neurotransmitter transport|
|regulation of dopamine secretion|
|regulation of nitric-oxide synthase activity|
|regulation of acute inflammatory response|
|regulation of mast cell activation|
|negative regulation of blood pressure|
|neuron recognition|
|response to nicotine|
|regulation of action potential|
|positive regulation of regulated secretory pathway|
|regulation of lipid catabolic process|
|regulation of monooxygenase activity|
|response to cocaine|
|drug binding|
|integral component of presynaptic membrane|
|regulation of catecholamine secretion|
|maternal process involved in female pregnancy|
|GABA-ergic synapse|
|regulation of synaptic transmission, glutamatergic|
|regulation of behavior|
|sensory perception of pain|
|response to anesthetic|
|regulation of synaptic vesicle exocytosis|
|negative regulation of lipid metabolic process|
|regulation of fatty acid metabolic process|
|positive regulation of exocytosis|
|negative regulation of small molecule metabolic process|
|regulation of amine transport|
|regulation of oxidoreductase activity|
|regulation of response to drug|
|regulation of neurotransmitter secretion|
|response to alkaloid|
|regulation of synaptic vesicle cycle|
|memory|
|response to ethanol|
|growth cone|
|positive regulation of inflammatory response|
|regulation of neurotransmitter transport|
|negative regulation of ion transport|
|positive regulation of synaptic transmission|
|regulation of reproductive process|
|mitochondrial outer membrane|
|regulation of regulated secretory pathway|
|regulation of cellular ketone metabolic process|
|negative regulation of leukocyte activation|
|regulation of insulin secretion|
|female pregnancy|
|regulation of blood pressure|
|response to ammonium ion|
|glucose homeostasis|
|carbohydrate homeostasis|
|negative regulation of cell activation|
|negative regulation of secretion by cell|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of peptide hormone secretion|
|multi-multicellular organism process|
|response to nutrient|
|regulation of exocytosis|
|membrane raft|
|negative regulation of secretion|
|response to alcohol|
|cell recognition|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|negative regulation of cellular catabolic process|
|learning or memory|
|regulation of hormone secretion|
|aging|
|positive regulation of neuron projection development|
|positive regulation of cytosolic calcium ion concentration|
|cognition|
|response to xenobiotic stimulus|
|response to antibiotic|
|negative regulation of catabolic process|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|regulation of cytosolic calcium ion concentration|
|regulation of inflammatory response|
|anatomical structure homeostasis|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|blood circulation|
|regulation of lipid metabolic process|
|circulatory system process|
|positive regulation of secretion by cell|
|axon development|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|regulation of small molecule metabolic process|
|regulation of membrane potential|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|negative regulation of immune system process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|synaptic signaling|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|positive regulation of defense response|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|regulation of neuron projection development|
|response to nutrient levels|
|response to toxic substance|
|response to extracellular stimulus|
|regulation of hormone levels|
|positive regulation of nervous system development|
|positive regulation of cell development|
|spermatogenesis|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|male gamete generation|
|behavior|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|regulation of cell activation|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|neuron projection development|
|response to bacterium|
|gamete generation|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of ion transport|
|cation homeostasis|
|regulation of protein transport|
|regulation of cell projection organization|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of multi-organism process|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|response to lipid|
|positive regulation of immune response|
|cellular homeostasis|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|sensory perception|
|positive regulation of transport|
|multi-organism reproductive process|
|regulation of catabolic process|
|response to organonitrogen compound|
|neuron differentiation|
|response to drug|
|regulation of protein localization|
|response to nitrogen compound|
|regulation of response to external stimulus|
|chemical homeostasis|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|positive regulation of cellular component organization|
|response to other organism|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|positive regulation of developmental process|
|nervous system process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|regulation of response to stress|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.7|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.79|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6481
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CNR1 Expression in NALM6 Cells: 3.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>