CNR1
Gene Information
- Official Symbol: CNR1
- Official Name: cannabinoid receptor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1268
- UniProt: P21554
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| 7TM GPCR Srsx |
| 7tm 1 |
GO Terms
| retrograde trans-synaptic signaling by endocannabinoid |
| negative regulation of dopamine secretion |
| trans-synaptic signaling by lipid, modulating synaptic transmission |
| trans-synaptic signaling by endocannabinoid, modulating synaptic transmission |
| retrograde trans-synaptic signaling by lipid |
| cannabinoid receptor activity |
| positive regulation of presynaptic cytosolic calcium concentration |
| induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration |
| voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels |
| negative regulation of fatty acid beta-oxidation |
| cannabinoid signaling pathway |
| trans-synaptic signaling by lipid |
| trans-synaptic signaling by endocannabinoid |
| negative regulation of nitric-oxide synthase activity |
| positive regulation of fever generation |
| retrograde trans-synaptic signaling |
| regulation of penile erection |
| regulation of fever generation |
| positive regulation of acute inflammatory response to antigenic stimulus |
| negative regulation of action potential |
| positive regulation of synaptic vesicle exocytosis |
| integral component of mitochondrial membrane |
| negative regulation of fatty acid oxidation |
| negative regulation of monooxygenase activity |
| positive regulation of heat generation |
| positive regulation of inflammatory response to antigenic stimulus |
| trans-synaptic signaling, modulating synaptic transmission |
| regulation of heat generation |
| regulation of acute inflammatory response to antigenic stimulus |
| negative regulation of mast cell activation |
| presynaptic modulation of chemical synaptic transmission |
| negative regulation of catecholamine secretion |
| regulation of presynaptic cytosolic calcium ion concentration |
| regulation of fatty acid beta-oxidation |
| positive regulation of neurotransmitter secretion |
| neuron projection fasciculation |
| axonal fasciculation |
| negative regulation of lipid catabolic process |
| negative regulation of oxidoreductase activity |
| regulation of inflammatory response to antigenic stimulus |
| negative regulation of fatty acid metabolic process |
| negative regulation of amine transport |
| negative regulation of response to drug |
| regulation of feeding behavior |
| positive regulation of acute inflammatory response |
| regulation of fatty acid oxidation |
| regulation of synaptic transmission, GABAergic |
| response to morphine |
| response to isoquinoline alkaloid |
| neuron cellular homeostasis |
| positive regulation of blood pressure |
| positive regulation of neurotransmitter transport |
| regulation of dopamine secretion |
| regulation of nitric-oxide synthase activity |
| regulation of acute inflammatory response |
| regulation of mast cell activation |
| negative regulation of blood pressure |
| neuron recognition |
| response to nicotine |
| regulation of action potential |
| positive regulation of regulated secretory pathway |
| regulation of lipid catabolic process |
| regulation of monooxygenase activity |
| response to cocaine |
| drug binding |
| integral component of presynaptic membrane |
| regulation of catecholamine secretion |
| maternal process involved in female pregnancy |
| GABA-ergic synapse |
| regulation of synaptic transmission, glutamatergic |
| regulation of behavior |
| sensory perception of pain |
| response to anesthetic |
| regulation of synaptic vesicle exocytosis |
| negative regulation of lipid metabolic process |
| regulation of fatty acid metabolic process |
| positive regulation of exocytosis |
| negative regulation of small molecule metabolic process |
| regulation of amine transport |
| regulation of oxidoreductase activity |
| regulation of response to drug |
| regulation of neurotransmitter secretion |
| response to alkaloid |
| regulation of synaptic vesicle cycle |
| memory |
| response to ethanol |
| growth cone |
| positive regulation of inflammatory response |
| regulation of neurotransmitter transport |
| negative regulation of ion transport |
| positive regulation of synaptic transmission |
| regulation of reproductive process |
| mitochondrial outer membrane |
| regulation of regulated secretory pathway |
| regulation of cellular ketone metabolic process |
| negative regulation of leukocyte activation |
| regulation of insulin secretion |
| female pregnancy |
| regulation of blood pressure |
| response to ammonium ion |
| glucose homeostasis |
| carbohydrate homeostasis |
| negative regulation of cell activation |
| negative regulation of secretion by cell |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| regulation of peptide hormone secretion |
| multi-multicellular organism process |
| response to nutrient |
| regulation of exocytosis |
| membrane raft |
| negative regulation of secretion |
| response to alcohol |
| cell recognition |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| negative regulation of cellular catabolic process |
| learning or memory |
| regulation of hormone secretion |
| aging |
| positive regulation of neuron projection development |
| positive regulation of cytosolic calcium ion concentration |
| cognition |
| response to xenobiotic stimulus |
| response to antibiotic |
| negative regulation of catabolic process |
| response to lipopolysaccharide |
| response to molecule of bacterial origin |
| regulation of cytosolic calcium ion concentration |
| regulation of inflammatory response |
| anatomical structure homeostasis |
| glutamatergic synapse |
| regulation of neurotransmitter levels |
| positive regulation of neuron differentiation |
| positive regulation of cell projection organization |
| blood circulation |
| regulation of lipid metabolic process |
| circulatory system process |
| positive regulation of secretion by cell |
| axon development |
| chemical synaptic transmission |
| anterograde trans-synaptic signaling |
| regulation of small molecule metabolic process |
| regulation of membrane potential |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| trans-synaptic signaling |
| negative regulation of immune system process |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| calcium ion homeostasis |
| synaptic signaling |
| regulation of protein secretion |
| cellular divalent inorganic cation homeostasis |
| positive regulation of neurogenesis |
| positive regulation of defense response |
| negative regulation of transport |
| divalent inorganic cation homeostasis |
| regulation of peptide secretion |
| regulation of neuron projection development |
| response to nutrient levels |
| response to toxic substance |
| response to extracellular stimulus |
| regulation of hormone levels |
| positive regulation of nervous system development |
| positive regulation of cell development |
| spermatogenesis |
| regulation of vesicle-mediated transport |
| cellular metal ion homeostasis |
| male gamete generation |
| behavior |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| metal ion homeostasis |
| cellular cation homeostasis |
| regulation of cell activation |
| positive regulation of apoptotic process |
| cellular ion homeostasis |
| positive regulation of programmed cell death |
| regulation of neuron differentiation |
| neuron projection development |
| response to bacterium |
| gamete generation |
| regulation of plasma membrane bounded cell projection organization |
| positive regulation of cell death |
| regulation of ion transport |
| cation homeostasis |
| regulation of protein transport |
| regulation of cell projection organization |
| inorganic ion homeostasis |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| regulation of multi-organism process |
| ion homeostasis |
| negative regulation of catalytic activity |
| regulation of secretion |
| neuron development |
| regulation of neurogenesis |
| multicellular organismal reproductive process |
| sexual reproduction |
| regulation of cellular catabolic process |
| multicellular organism reproduction |
| response to lipid |
| positive regulation of immune response |
| cellular homeostasis |
| regulation of cellular localization |
| response to organic cyclic compound |
| regulation of nervous system development |
| regulation of cell development |
| positive regulation of cell differentiation |
| sensory perception |
| positive regulation of transport |
| multi-organism reproductive process |
| regulation of catabolic process |
| response to organonitrogen compound |
| neuron differentiation |
| response to drug |
| regulation of protein localization |
| response to nitrogen compound |
| regulation of response to external stimulus |
| chemical homeostasis |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| negative regulation of molecular function |
| positive regulation of immune system process |
| regulation of immune response |
| cell projection organization |
| positive regulation of cellular component organization |
| response to other organism |
| response to external biotic stimulus |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| positive regulation of developmental process |
| nervous system process |
| integral component of plasma membrane |
| reproductive process |
| reproduction |
| regulation of response to stress |
| generation of neurons |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| negative regulation of response to stimulus |
| neurogenesis |
| homeostatic process |
| cell development |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Isonicotinamide 500μM R03 exp129 | 1.7 |
| Cryptotanshinone 12μM R05 exp227 | 1.79 |
| Ribavirin 10μM R01 exp52 | 1.9 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6481
- Expression level (log2 read counts): 3.93
Expression Distribution
CNR1 Expression in NALM6 Cells: 3.93
