CNR2 [The Human Chemical-Genetic Interaction Map Project]

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======= CNR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CNR2
  * **<color #00a2e8>Official Name</color>**: cannabinoid receptor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1269|1269]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P34972|P34972]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CNR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CNR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605051|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. {ECO:0000269|PubMed:10051546, ECO:0000269|PubMed:12663043, ECO:0000269|PubMed:12711605, ECO:0000269|PubMed:18692962}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srsx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cannabinoid receptor activity|
|cannabinoid signaling pathway|
|negative regulation of synaptic transmission, GABAergic|
|negative regulation of nitric-oxide synthase activity|
|negative regulation of action potential|
|negative regulation of monooxygenase activity|
|negative regulation of mast cell activation|
|negative regulation of oxidoreductase activity|
|regulation of synaptic transmission, GABAergic|
|response to amphetamine|
|regulation of nitric-oxide synthase activity|
|regulation of mast cell activation|
|response to amine|
|regulation of action potential|
|response to bronchodilator|
|regulation of monooxygenase activity|
|negative regulation of synaptic transmission|
|extrinsic component of cytoplasmic side of plasma membrane|
|sensory perception of pain|
|regulation of oxidoreductase activity|
|perikaryon|
|negative regulation of inflammatory response|
|leukocyte chemotaxis|
|negative regulation of leukocyte activation|
|negative regulation of cell activation|
|negative regulation of defense response|
|cell chemotaxis|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|response to xenobiotic stimulus|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|regulation of inflammatory response|
|negative regulation of response to external stimulus|
|leukocyte migration|
|dendrite|
|regulation of membrane potential|
|negative regulation of immune system process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|inflammatory response|
|response to toxic substance|
|chemotaxis|
|taxis|
|regulation of leukocyte activation|
|regulation of cell activation|
|response to bacterium|
|regulation of defense response|
|negative regulation of catalytic activity|
|response to lipid|
|cell migration|
|sensory perception|
|response to organonitrogen compound|
|response to drug|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|regulation of response to external stimulus|
|negative regulation of molecular function|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|integral component of plasma membrane|
|regulation of response to stress|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|regulation of immune system process|
|immune response|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.21|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13602
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CNR2 Expression in NALM6 Cells: 3.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>