CNR2

Entrez Summary: N/A
UniProt Summary: Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. {ECO:0000269|PubMed:10051546, ECO:0000269|PubMed:12663043, ECO:0000269|PubMed:12711605, ECO:0000269|PubMed:18692962}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Lapatinib 5μM R01 exp47	-2.21
Senexin-A 25μM R07 exp400	-1.89

7tm 1
7TM GPCR Srsx

cannabinoid receptor activity
cannabinoid signaling pathway
negative regulation of synaptic transmission, GABAergic
negative regulation of nitric-oxide synthase activity
negative regulation of action potential
negative regulation of monooxygenase activity
negative regulation of mast cell activation
negative regulation of oxidoreductase activity
regulation of synaptic transmission, GABAergic
response to amphetamine
regulation of nitric-oxide synthase activity
regulation of mast cell activation
response to amine
regulation of action potential
response to bronchodilator
regulation of monooxygenase activity
negative regulation of synaptic transmission
extrinsic component of cytoplasmic side of plasma membrane
sensory perception of pain
regulation of oxidoreductase activity
perikaryon
negative regulation of inflammatory response
leukocyte chemotaxis
negative regulation of leukocyte activation
negative regulation of cell activation
negative regulation of defense response
cell chemotaxis
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
response to xenobiotic stimulus
response to lipopolysaccharide
response to molecule of bacterial origin
regulation of inflammatory response
negative regulation of response to external stimulus
leukocyte migration
dendrite
regulation of membrane potential
negative regulation of immune system process
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
inflammatory response