CNTN6

Entrez Summary: The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
UniProt Summary: Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

anchored component of presynaptic membrane
parallel fiber to Purkinje cell synapse
dendrite self-avoidance
cell-cell adhesion mediator activity
Notch binding
neuron recognition
positive regulation of Notch signaling pathway
regulation of Notch signaling pathway
Notch signaling pathway
homophilic cell adhesion via plasma membrane adhesion molecules
cell recognition
cell-cell adhesion via plasma-membrane adhesion molecules
axon guidance
neuron projection guidance
axon
axonogenesis
axon development
cell morphogenesis involved in neuron differentiation
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell-cell adhesion
cell part morphogenesis
chemotaxis
taxis
cell morphogenesis involved in differentiation
neuron projection development
cell morphogenesis
neuron development
cellular component morphogenesis
cell adhesion
biological adhesion
central nervous system development
neuron differentiation
plasma membrane bounded cell projection organization
cell projection organization
locomotion
generation of neurons
movement of cell or subcellular component
neurogenesis