CNTROB

Official Symbol: CNTROB
Official Name: centrobin, centriole duplication and spindle assembly protein
Aliases and Previous Symbols: N/A
Entrez ID: 116840
UniProt: Q8N137
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: This gene encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication and cytokinesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].
UniProt Summary: Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. {ECO:0000269|PubMed:16275750}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

centrosome separation
centriole replication
mitotic cytokinetic process
centriole assembly
centrosome duplication
cytokinetic process
mitotic cytokinesis
regulation of cilium assembly
centrosome cycle
microtubule organizing center organization
cytoskeleton-dependent cytokinesis
cytokinesis
centriole
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
regulation of organelle assembly
protein domain specific binding
microtubule cytoskeleton organization
centrosome
cell division
mitotic cell cycle process
microtubule-based process
mitotic cell cycle
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
organelle assembly
regulation of cellular component biogenesis
cell cycle process
cytoskeleton organization
regulation of organelle organization
cell cycle