COLEC10

Entrez Summary: N/A
UniProt Summary: Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine (PubMed:10224141). Acts as a chemoattractant, probably involved in the regulation of cell migration (PubMed:28301481). {ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Prochlorperazine 5.2μM R02 exp77	1.76
5-Fluorouracil 20μM R00 exp2	1.9

Lectin C
Collagen

complement activation, lectin pathway
monosaccharide binding
mannose binding
chemoattractant activity
positive chemotaxis
collagen trimer
cranial skeletal system development
complement activation
humoral immune response
chemotaxis
taxis
activation of immune response
innate immune response
positive regulation of immune response
defense response to other organism
Golgi apparatus
immune effector process
positive regulation of immune system process
regulation of immune response
response to other organism
response to external biotic stimulus
locomotion
response to biotic stimulus
defense response
extracellular space
regulation of immune system process
immune response
extracellular region