COQ9 [The Human Chemical-Genetic Interaction Map Project]

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======= COQ9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COQ9
  * **<color #00a2e8>Official Name</color>**: coenzyme Q9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57017|57017]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75208|O75208]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COQ9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COQ9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612837|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This locus represents a mitochondrial ubiquinone biosynthesis gene. The encoded protein is likely necessary for biosynthesis of coenzyme Q10, as mutations at this locus have been associated with autosomal-recessive neonatal-onset primary coenzyme Q10 deficiency.[provided by RefSeq, Sep 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7. {ECO:0000269|PubMed:25339443}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COQ9|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquinone biosynthetic process|
|quinone biosynthetic process|
|ubiquinone metabolic process|
|ketone biosynthetic process|
|quinone metabolic process|
|mitochondrial electron transport, NADH to ubiquinone|
|oxidoreduction coenzyme metabolic process|
|cellular ketone metabolic process|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|respiratory electron transport chain|
|oxidative phosphorylation|
|coenzyme biosynthetic process|
|lipid binding|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|cofactor biosynthetic process|
|energy derivation by oxidation of organic compounds|
|coenzyme metabolic process|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|cofactor metabolic process|
|small molecule biosynthetic process|
|protein homodimerization activity|
|oxidation-reduction process|
|mitochondrion|
|phosphorylation|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-2.2|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.99|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|-1.97|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.83|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.92|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.93|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.95|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3580
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COQ9 Expression in NALM6 Cells: 5.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>