COQ9

Entrez Summary: This locus represents a mitochondrial ubiquinone biosynthesis gene. The encoded protein is likely necessary for biosynthesis of coenzyme Q10, as mutations at this locus have been associated with autosomal-recessive neonatal-onset primary coenzyme Q10 deficiency.[provided by RefSeq, Sep 2010].
UniProt Summary: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7. {ECO:0000269|PubMed:25339443}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SGC2043 10μM R03 exp152	-2.2
GSK-J4 1μM R07 exp362	-1.99
Lead acetate 990μM R08 exp496	-1.97
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	1.83
Dynasore 7μM R08 exp436	1.92
Nocodazole 0.2μM R02 exp64	1.93
Dexamethasone 0.006μM R07 exp351	1.95
Lead acetate 2000μM R08 exp497	2

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ubiquinone biosynthetic process
quinone biosynthetic process
ubiquinone metabolic process
ketone biosynthetic process
quinone metabolic process
mitochondrial electron transport, NADH to ubiquinone
oxidoreduction coenzyme metabolic process
cellular ketone metabolic process
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
respiratory electron transport chain
oxidative phosphorylation
coenzyme biosynthetic process
lipid binding
cellular respiration
electron transport chain
ATP metabolic process
cofactor biosynthetic process
energy derivation by oxidation of organic compounds
coenzyme metabolic process
mitochondrial inner membrane
generation of precursor metabolites and energy
cofactor metabolic process
small molecule biosynthetic process
protein homodimerization activity
oxidation-reduction process
mitochondrion
phosphorylation
small molecule metabolic process