CORO1C [The Human Chemical-Genetic Interaction Map Project]

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======= CORO1C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CORO1C
  * **<color #00a2e8>Official Name</color>**: coronin 1C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23603|23603]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULV4|Q9ULV4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CORO1C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CORO1C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605269|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in cytokinesis, motility, and signal transduction. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
|DUF1899|
|DUF1900|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endosome fission|
|endosome membrane tubulation|
|membrane tubulation|
|positive regulation of lamellipodium morphogenesis|
|flotillin complex|
|negative regulation of protein kinase activity by regulation of protein phosphorylation|
|regulation of lamellipodium morphogenesis|
|membrane fission|
|negative regulation of substrate adhesion-dependent cell spreading|
|negative regulation of focal adhesion assembly|
|negative regulation of adherens junction organization|
|negative regulation of cell junction assembly|
|positive regulation of lamellipodium organization|
|regulation of ruffle assembly|
|regulation of fibroblast migration|
|negative regulation of cell-matrix adhesion|
|regulation of lamellipodium organization|
|sarcomere|
|regulation of substrate adhesion-dependent cell spreading|
|Rac GTPase binding|
|neural crest cell migration|
|lateral plasma membrane|
|regulation of cell-substrate junction assembly|
|regulation of focal adhesion assembly|
|negative regulation of cell-substrate adhesion|
|negative regulation of epithelial cell migration|
|regulation of adherens junction organization|
|endosome organization|
|neural crest cell development|
|stem cell development|
|mesenchymal cell development|
|neural crest cell differentiation|
|regulation of cell junction assembly|
|ruffle membrane|
|activation of GTPase activity|
|negative regulation of cell morphogenesis involved in differentiation|
|sarcolemma|
|regulation of cell-matrix adhesion|
|cell cortex|
|vesicle|
|mesenchymal cell differentiation|
|stem cell differentiation|
|ameboidal-type cell migration|
|lamellipodium|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|actin filament binding|
|regulation of cell-substrate adhesion|
|endosome membrane|
|actin cytoskeleton|
|regulation of epithelial cell migration|
|mesenchyme development|
|negative regulation of protein kinase activity|
|endosomal transport|
|actin filament organization|
|negative regulation of kinase activity|
|negative regulation of cell migration|
|synapse|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|negative regulation of transferase activity|
|vesicle organization|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cellular component movement|
|organelle fission|
|negative regulation of locomotion|
|phagocytosis|
|negative regulation of cell development|
|positive regulation of cell projection organization|
|negative regulation of protein phosphorylation|
|positive regulation of GTPase activity|
|focal adhesion|
|endomembrane system organization|
|negative regulation of phosphorylation|
|supramolecular fiber organization|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|actin filament-based process|
|negative regulation of protein modification process|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|positive regulation of hydrolase activity|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of cell migration|
|membrane organization|
|regulation of kinase activity|
|regulation of cell motility|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|cell migration|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cellular protein metabolic process|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|locomotion|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|intracellular transport|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|establishment of protein localization|
|cell development|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|establishment of localization in cell|
|regulation of protein modification process|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-1.8|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.72|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.7|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.72|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17024
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CORO1C Expression in NALM6 Cells: 7.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>