CORO1C
Gene Information
- Official Symbol: CORO1C
- Official Name: coronin 1C
- Aliases and Previous Symbols: N/A
- Entrez ID: 23603
- UniProt: Q9ULV4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May be involved in cytokinesis, motility, and signal transduction. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| WD40 |
| DUF1899 |
| DUF1900 |
GO Terms
| endosome fission |
| endosome membrane tubulation |
| membrane tubulation |
| positive regulation of lamellipodium morphogenesis |
| flotillin complex |
| negative regulation of protein kinase activity by regulation of protein phosphorylation |
| regulation of lamellipodium morphogenesis |
| membrane fission |
| negative regulation of substrate adhesion-dependent cell spreading |
| negative regulation of focal adhesion assembly |
| negative regulation of adherens junction organization |
| negative regulation of cell junction assembly |
| positive regulation of lamellipodium organization |
| regulation of ruffle assembly |
| regulation of fibroblast migration |
| negative regulation of cell-matrix adhesion |
| regulation of lamellipodium organization |
| sarcomere |
| regulation of substrate adhesion-dependent cell spreading |
| Rac GTPase binding |
| neural crest cell migration |
| lateral plasma membrane |
| regulation of cell-substrate junction assembly |
| regulation of focal adhesion assembly |
| negative regulation of cell-substrate adhesion |
| negative regulation of epithelial cell migration |
| regulation of adherens junction organization |
| endosome organization |
| neural crest cell development |
| stem cell development |
| mesenchymal cell development |
| neural crest cell differentiation |
| regulation of cell junction assembly |
| ruffle membrane |
| activation of GTPase activity |
| negative regulation of cell morphogenesis involved in differentiation |
| sarcolemma |
| regulation of cell-matrix adhesion |
| cell cortex |
| vesicle |
| mesenchymal cell differentiation |
| stem cell differentiation |
| ameboidal-type cell migration |
| lamellipodium |
| regulation of plasma membrane bounded cell projection assembly |
| regulation of cell projection assembly |
| actin filament binding |
| regulation of cell-substrate adhesion |
| endosome membrane |
| actin cytoskeleton |
| regulation of epithelial cell migration |
| mesenchyme development |
| negative regulation of protein kinase activity |
| endosomal transport |
| actin filament organization |
| negative regulation of kinase activity |
| negative regulation of cell migration |
| synapse |
| negative regulation of cell adhesion |
| negative regulation of cell motility |
| negative regulation of transferase activity |
| vesicle organization |
| regulation of cell morphogenesis involved in differentiation |
| negative regulation of cellular component movement |
| organelle fission |
| negative regulation of locomotion |
| phagocytosis |
| negative regulation of cell development |
| positive regulation of cell projection organization |
| negative regulation of protein phosphorylation |
| positive regulation of GTPase activity |
| focal adhesion |
| endomembrane system organization |
| negative regulation of phosphorylation |
| supramolecular fiber organization |
| regulation of GTPase activity |
| regulation of cell morphogenesis |
| actin cytoskeleton organization |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| actin filament-based process |
| negative regulation of protein modification process |
| regulation of cell adhesion |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| positive regulation of hydrolase activity |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of cell migration |
| membrane organization |
| regulation of kinase activity |
| regulation of cell motility |
| regulation of cell development |
| negative regulation of developmental process |
| regulation of cellular component biogenesis |
| cell migration |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| negative regulation of cellular protein metabolic process |
| regulation of anatomical structure morphogenesis |
| localization of cell |
| cell motility |
| negative regulation of protein metabolic process |
| cytoskeleton organization |
| negative regulation of molecular function |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| regulation of hydrolase activity |
| locomotion |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| intracellular transport |
| movement of cell or subcellular component |
| regulation of phosphorylation |
| establishment of protein localization |
| cell development |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| establishment of localization in cell |
| regulation of protein modification process |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Tenofovir 10μM R07 exp405 | -1.8 |
| All-trans-Retinoic-Acid 40μM R07 exp334 | -1.72 |
| ML-792 0.2μM R08 exp505 | -1.7 |
| PNU96415E 10μM R03 exp145 | 1.72 |
| IU1-C 25μM R04 exp183 | 1.74 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17024
- Expression level (log2 read counts): 7.46
Expression Distribution
CORO1C Expression in NALM6 Cells: 7.46
