COTL1

Entrez Summary: N/A
UniProt Summary: Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis. {ECO:0000269|PubMed:11583571, ECO:0000269|PubMed:19807693}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

defense response to fungus
response to fungus
cortical actin cytoskeleton
actin filament
secretory granule lumen
ficolin-1-rich granule lumen
regulation of actin filament polymerization
regulation of actin polymerization or depolymerization
regulation of actin filament length
actin filament binding
regulation of protein polymerization
regulation of actin filament organization
actin binding
regulation of actin cytoskeleton organization
enzyme binding
regulation of supramolecular fiber organization
cytoskeleton
regulation of cellular component size
regulation of actin filament-based process
regulation of protein complex assembly
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
regulation of anatomical structure size
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
regulation of cytoskeleton organization
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis
leukocyte mediated immunity
exocytosis
leukocyte activation
defense response to other organism
regulation of cellular component biogenesis
secretion by cell