CPSF1 [The Human Chemical-Genetic Interaction Map Project]

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======= CPSF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CPSF1
  * **<color #00a2e8>Official Name</color>**: cleavage and polyadenylation specific factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29894|29894]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q10570|Q10570]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CPSF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CPSF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606027|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction. {ECO:0000269|PubMed:14749727}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MMS1 N|
|CPSF A|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pre-mRNA cleavage required for polyadenylation|
|mRNA cleavage involved in mRNA processing|
|tRNA splicing, via endonucleolytic cleavage and ligation|
|RNA splicing, via endonucleolytic cleavage and ligation|
|mRNA cleavage and polyadenylation specificity factor complex|
|mRNA cleavage|
|mRNA 3-UTR AU-rich region binding|
|mRNA polyadenylation|
|RNA polyadenylation|
|termination of RNA polymerase II transcription|
|DNA-templated transcription, termination|
|mRNA 3-end processing|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|tRNA processing|
|RNA 3-end processing|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|RNA phosphodiester bond hydrolysis|
|tRNA metabolic process|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|RNA localization|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|nucleic acid phosphodiester bond hydrolysis|
|RNA splicing, via transesterification reactions|
|enzyme binding|
|ncRNA processing|
|RNA splicing|
|ncRNA metabolic process|
|mRNA processing|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|RNA processing|
|intracellular protein transport|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.91|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.89|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.74|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-1.7|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.79|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.85|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.87|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 715/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/25|
|breast|31/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|73/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|6/7|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 76
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CPSF1 Expression in NALM6 Cells: 7.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>