CPSF1

Entrez Summary: N/A
UniProt Summary: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction. {ECO:0000269|PubMed:14749727}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 715/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	25/25
breast	31/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	15/15
kidney	21/21
liver	20/20
lung	73/75
lymphocyte	14/14
ovary	26/26
pancreas	24/24
peripheral nervous system	15/16
plasma cell	15/15
prostate	1/1
skin	23/24
soft tissue	6/7
thyroid	2/2
upper aerodigestive	20/22
urinary tract	29/29
uterus	5/5

Expression Distribution

MMS1 N
CPSF A

pre-mRNA cleavage required for polyadenylation
mRNA cleavage involved in mRNA processing
tRNA splicing, via endonucleolytic cleavage and ligation
RNA splicing, via endonucleolytic cleavage and ligation
mRNA cleavage and polyadenylation specificity factor complex
mRNA cleavage
mRNA 3-UTR AU-rich region binding
mRNA polyadenylation
RNA polyadenylation
termination of RNA polymerase II transcription
DNA-templated transcription, termination
mRNA 3-end processing
mRNA export from nucleus
mRNA-containing ribonucleoprotein complex export from nucleus
ribonucleoprotein complex export from nucleus
ribonucleoprotein complex localization
RNA export from nucleus
tRNA processing
RNA 3-end processing
protein export from nucleus
mRNA transport
nuclear export
RNA phosphodiester bond hydrolysis
tRNA metabolic process
nucleic acid transport
RNA transport
establishment of RNA localization
RNA localization
nucleobase-containing compound transport
protein-containing complex localization
nucleocytoplasmic transport
nuclear transport
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
nucleic acid phosphodiester bond hydrolysis
RNA splicing, via transesterification reactions
enzyme binding
ncRNA processing
RNA splicing
ncRNA metabolic process