CREB3L1 [The Human Chemical-Genetic Interaction Map Project]

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======= CREB3L1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CREB3L1
  * **<color #00a2e8>Official Name</color>**: cAMP responsive element binding protein 3 like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=90993|90993]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96BA8|Q96BA8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CREB3L1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CREB3L1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616215|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (PubMed:21767813). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (By similarity). Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix (PubMed:25310401). {ECO:0000250|UniProtKB:Q9Z125, ECO:0000269|PubMed:12054625, ECO:0000269|PubMed:21767813, ECO:0000269|PubMed:25310401}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|bZIP 1|
|bZIP 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extracellular matrix constituent secretion|
|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|
|cAMP response element binding|
|negative regulation of fibroblast growth factor receptor signaling pathway|
|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|negative regulation of sprouting angiogenesis|
|positive regulation of collagen biosynthetic process|
|positive regulation of collagen metabolic process|
|regulation of fibroblast growth factor receptor signaling pathway|
|positive regulation of transcription from RNA polymerase II promoter in response to stress|
|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|regulation of collagen biosynthetic process|
|regulation of collagen metabolic process|
|negative regulation of response to endoplasmic reticulum stress|
|SMAD binding|
|regulation of sprouting angiogenesis|
|regulation of response to endoplasmic reticulum stress|
|negative regulation of intrinsic apoptotic signaling pathway|
|negative regulation of angiogenesis|
|endoplasmic reticulum unfolded protein response|
|negative regulation of blood vessel morphogenesis|
|negative regulation of vasculature development|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|regulation of DNA-templated transcription in response to stress|
|cellular response to unfolded protein|
|osteoblast differentiation|
|negative regulation of cellular response to growth factor stimulus|
|cellular response to topologically incorrect protein|
|regulation of intrinsic apoptotic signaling pathway|
|response to unfolded protein|
|response to topologically incorrect protein|
|transcription regulatory region DNA binding|
|negative regulation of apoptotic signaling pathway|
|nuclear chromatin|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|response to endoplasmic reticulum stress|
|ossification|
|regulation of cellular response to growth factor stimulus|
|regulation of angiogenesis|
|regulation of vasculature development|
|extracellular matrix organization|
|extracellular structure organization|
|chromatin binding|
|regulation of apoptotic signaling pathway|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|negative regulation of intracellular signal transduction|
|regulation of cellular response to stress|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|negative regulation of cell death|
|secretion by cell|
|endoplasmic reticulum|
|export from cell|
|regulation of anatomical structure morphogenesis|
|secretion|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of cell death|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.75|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4246
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CREB3L1 Expression in NALM6 Cells: 1.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>