CREB3L1

Gene Information

Official Symbol: CREB3L1
Official Name: cAMP responsive element binding protein 3 like 1
Aliases and Previous Symbols: N/A
Entrez ID: 90993
UniProt: Q96BA8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013].
UniProt Summary: Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (PubMed:21767813). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (By similarity). Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix (PubMed:25310401). {ECO:0000250|UniProtKB:Q9Z125, ECO:0000269|PubMed:12054625, ECO:0000269|PubMed:21767813, ECO:0000269|PubMed:25310401}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4246
Expression level (log2 read counts): 1.87

Expression Distribution

Screen	Score
CAY10603 0.55μM R08 exp467	1.75
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	1.78

bZIP 1
bZIP 2

extracellular matrix constituent secretion
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
cAMP response element binding
negative regulation of fibroblast growth factor receptor signaling pathway
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of sprouting angiogenesis
positive regulation of collagen biosynthetic process
positive regulation of collagen metabolic process
regulation of fibroblast growth factor receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter in response to stress
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
regulation of collagen biosynthetic process
regulation of collagen metabolic process
negative regulation of response to endoplasmic reticulum stress
SMAD binding
regulation of sprouting angiogenesis
regulation of response to endoplasmic reticulum stress
negative regulation of intrinsic apoptotic signaling pathway
negative regulation of angiogenesis
endoplasmic reticulum unfolded protein response
negative regulation of blood vessel morphogenesis
negative regulation of vasculature development
regulation of transcription from RNA polymerase II promoter in response to stress
regulation of DNA-templated transcription in response to stress
cellular response to unfolded protein
osteoblast differentiation
negative regulation of cellular response to growth factor stimulus
cellular response to topologically incorrect protein
regulation of intrinsic apoptotic signaling pathway
response to unfolded protein
response to topologically incorrect protein
transcription regulatory region DNA binding
negative regulation of apoptotic signaling pathway
nuclear chromatin
DNA-binding transcription repressor activity, RNA polymerase II-specific
response to endoplasmic reticulum stress
ossification
regulation of cellular response to growth factor stimulus
regulation of angiogenesis
regulation of vasculature development