CREM

Entrez Summary: This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cAMP response element binding protein binding
retinoic acid receptor signaling pathway
glycosphingolipid metabolic process
glycolipid metabolic process
liposaccharide metabolic process
glucose metabolic process
regulation of circadian rhythm
sphingolipid metabolic process
hexose metabolic process
intracellular receptor signaling pathway
monosaccharide metabolic process
membrane lipid metabolic process
transcription factor complex
DNA-binding transcription repressor activity, RNA polymerase II-specific
rhythmic process
RNA polymerase II regulatory region sequence-specific DNA binding
fatty acid metabolic process
carbohydrate metabolic process
monocarboxylic acid metabolic process
spermatogenesis
male gamete generation
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
negative regulation of transcription by RNA polymerase II
carboxylic acid metabolic process
cellular lipid metabolic process
multi-organism reproductive process
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
negative regulation of transcription, DNA-templated
lipid metabolic process
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
reproductive process