CRMP1

Entrez Summary: N/A
UniProt Summary: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis. {ECO:0000269|PubMed:11562390, ECO:0000269|PubMed:19799413}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of actin filament binding
negative regulation of actin binding
regulation of actin filament binding
regulation of actin binding
dihydropyrimidinase activity
pyrimidine nucleobase catabolic process
nucleobase catabolic process
filamin binding
pyrimidine nucleobase metabolic process
nucleobase metabolic process
pyrimidine-containing compound catabolic process
negative regulation of protein binding
pyrimidine-containing compound metabolic process
spindle
negative regulation of neuron projection development
midbody
negative regulation of binding
negative regulation of cell projection organization
regulation of protein binding
negative regulation of neuron differentiation
axon guidance
neuron projection guidance
negative regulation of neurogenesis
negative regulation of nervous system development
negative regulation of cell development
axonogenesis
regulation of binding
axon development
cell morphogenesis involved in neuron differentiation
heterocycle catabolic process
cellular nitrogen compound catabolic process
microtubule cytoskeleton organization
neuron projection morphogenesis
organic cyclic compound catabolic process
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
centrosome
regulation of neuron projection development
cell part morphogenesis
nucleobase-containing small molecule metabolic process