CSF2 [The Human Chemical-Genetic Interaction Map Project]

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======= CSF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CSF2
  * **<color #00a2e8>Official Name</color>**: colony stimulating factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1437|1437]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04141|P04141]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CSF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CSF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138960|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. {ECO:0000269|PubMed:3925454}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GM CSF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|granulocyte macrophage colony-stimulating factor receptor binding|
|response to silicon dioxide|
|positive regulation of interleukin-23 production|
|negative regulation of cytolysis|
|neutrophil differentiation|
|histamine secretion|
|histamine transport|
|epithelial fluid transport|
|regulation of interleukin-23 production|
|cellular response to granulocyte macrophage colony-stimulating factor stimulus|
|response to granulocyte macrophage colony-stimulating factor|
|positive regulation of podosome assembly|
|positive regulation of macrophage derived foam cell differentiation|
|regulation of podosome assembly|
|regulation of circadian sleep/wake cycle, sleep|
|mononuclear cell differentiation|
|monocyte differentiation|
|regulation of cytolysis|
|transepithelial transport|
|azole transport|
|myeloid dendritic cell differentiation|
|granulocyte differentiation|
|regulation of circadian sleep/wake cycle|
|myeloid dendritic cell activation|
|macrophage differentiation|
|fluid transport|
|regulation of macrophage derived foam cell differentiation|
|dendritic cell differentiation|
|response to fluid shear stress|
|negative regulation of signal transduction in absence of ligand|
|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|macrophage activation|
|ammonium transport|
|positive regulation of tyrosine phosphorylation of STAT protein|
|regulation of behavior|
|positive regulation of organelle assembly|
|regulation of tyrosine phosphorylation of STAT protein|
|positive regulation of receptor signaling pathway via JAK-STAT|
|embryonic placenta development|
|positive regulation of receptor signaling pathway via STAT|
|negative regulation of extrinsic apoptotic signaling pathway|
|myeloid leukocyte differentiation|
|regulation of circadian rhythm|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|placenta development|
|regulation of extrinsic apoptotic signaling pathway|
|growth factor activity|
|cytokine activity|
|neurotransmitter transport|
|cellular response to lipopolysaccharide|
|positive regulation of peptidyl-tyrosine phosphorylation|
|cellular response to molecule of bacterial origin|
|cellular response to biotic stimulus|
|regulation of organelle assembly|
|myeloid cell differentiation|
|regulation of myeloid cell differentiation|
|negative regulation of apoptotic signaling pathway|
|positive regulation of protein complex assembly|
|regulation of peptidyl-tyrosine phosphorylation|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|leukocyte differentiation|
|MAPK cascade|
|in utero embryonic development|
|signal transduction by protein phosphorylation|
|regulation of apoptotic signaling pathway|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|positive regulation of cytokine production|
|regulation of protein complex assembly|
|regulation of hemopoiesis|
|positive regulation of cellular component biogenesis|
|cellular response to lipid|
|response to inorganic substance|
|hemopoiesis|
|myeloid leukocyte activation|
|hematopoietic or lymphoid organ development|
|positive regulation of organelle organization|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|cytokine-mediated signaling pathway|
|intracellular membrane-bounded organelle|
|response to bacterium|
|regulation of cytokine production|
|cation transport|
|response to lipid|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|leukocyte activation|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|protein phosphorylation|
|embryo development|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell activation|
|response to cytokine|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|phosphorylation|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|ion transport|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|nitrogen compound transport|
|regulation of protein modification process|
|immune response|
|extracellular region|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.71|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11889
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CSF2 Expression in NALM6 Cells: -3.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>