CSF2
Gene Information
- Official Symbol: CSF2
- Official Name: colony stimulating factor 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 1437
- UniProt: P04141
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008].
- UniProt Summary: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. {ECO:0000269|PubMed:3925454}.
Pfam Domains GO Terms
Pfam Domains
| GM CSF |
GO Terms
| granulocyte macrophage colony-stimulating factor receptor binding |
| response to silicon dioxide |
| positive regulation of interleukin-23 production |
| negative regulation of cytolysis |
| neutrophil differentiation |
| histamine secretion |
| histamine transport |
| epithelial fluid transport |
| regulation of interleukin-23 production |
| cellular response to granulocyte macrophage colony-stimulating factor stimulus |
| response to granulocyte macrophage colony-stimulating factor |
| positive regulation of podosome assembly |
| positive regulation of macrophage derived foam cell differentiation |
| regulation of podosome assembly |
| regulation of circadian sleep/wake cycle, sleep |
| mononuclear cell differentiation |
| monocyte differentiation |
| regulation of cytolysis |
| transepithelial transport |
| azole transport |
| myeloid dendritic cell differentiation |
| granulocyte differentiation |
| regulation of circadian sleep/wake cycle |
| myeloid dendritic cell activation |
| macrophage differentiation |
| fluid transport |
| regulation of macrophage derived foam cell differentiation |
| dendritic cell differentiation |
| response to fluid shear stress |
| negative regulation of signal transduction in absence of ligand |
| negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| macrophage activation |
| ammonium transport |
| positive regulation of tyrosine phosphorylation of STAT protein |
| regulation of behavior |
| positive regulation of organelle assembly |
| regulation of tyrosine phosphorylation of STAT protein |
| positive regulation of receptor signaling pathway via JAK-STAT |
| embryonic placenta development |
| positive regulation of receptor signaling pathway via STAT |
| negative regulation of extrinsic apoptotic signaling pathway |
| myeloid leukocyte differentiation |
| regulation of circadian rhythm |
| regulation of receptor signaling pathway via JAK-STAT |
| regulation of receptor signaling pathway via STAT |
| placenta development |
| regulation of extrinsic apoptotic signaling pathway |
| growth factor activity |
| cytokine activity |
| neurotransmitter transport |
| cellular response to lipopolysaccharide |
| positive regulation of peptidyl-tyrosine phosphorylation |
| cellular response to molecule of bacterial origin |
| cellular response to biotic stimulus |
| regulation of organelle assembly |
| myeloid cell differentiation |
| regulation of myeloid cell differentiation |
| negative regulation of apoptotic signaling pathway |
| positive regulation of protein complex assembly |
| regulation of peptidyl-tyrosine phosphorylation |
| response to lipopolysaccharide |
| response to molecule of bacterial origin |
| leukocyte differentiation |
| MAPK cascade |
| in utero embryonic development |
| signal transduction by protein phosphorylation |
| regulation of apoptotic signaling pathway |
| reproductive structure development |
| reproductive system development |
| embryonic organ development |
| positive regulation of cytokine production |
| regulation of protein complex assembly |
| regulation of hemopoiesis |
| positive regulation of cellular component biogenesis |
| cellular response to lipid |
| response to inorganic substance |
| hemopoiesis |
| myeloid leukocyte activation |
| hematopoietic or lymphoid organ development |
| positive regulation of organelle organization |
| chordate embryonic development |
| immune system development |
| embryo development ending in birth or egg hatching |
| developmental process involved in reproduction |
| cytokine-mediated signaling pathway |
| intracellular membrane-bounded organelle |
| response to bacterium |
| regulation of cytokine production |
| cation transport |
| response to lipid |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| positive regulation of cell population proliferation |
| leukocyte activation |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| protein phosphorylation |
| embryo development |
| negative regulation of cell death |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| cell activation |
| response to cytokine |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of transcription, DNA-templated |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| phosphorylation |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| ion transport |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| nitrogen compound transport |
| regulation of protein modification process |
| immune response |
| extracellular region |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Doxycycline 10μM R00 exp18 | -1.71 |
| MKC9989 10μM R03 exp133 | 1.93 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11889
- Expression level (log2 read counts): -3.13
Expression Distribution
CSF2 Expression in NALM6 Cells: -3.13
