CSGALNACT2

Gene Information

Official Symbol: CSGALNACT2
Official Name: chondroitin sulfate N-acetylgalactosaminyltransferase 2
Aliases and Previous Symbols: N/A
Entrez ID: 55454
UniProt: Q8N6G5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. {ECO:0000269|PubMed:12433924, ECO:0000269|PubMed:12446672}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7124
Expression level (log2 read counts): 5.23

Expression Distribution

dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
dermatan sulfate proteoglycan biosynthetic process
dermatan sulfate proteoglycan metabolic process
acetylgalactosaminyltransferase activity
chondroitin sulfate biosynthetic process
chondroitin sulfate proteoglycan biosynthetic process
chondroitin sulfate metabolic process
cellular polysaccharide biosynthetic process
chondroitin sulfate proteoglycan metabolic process
polysaccharide biosynthetic process
cellular carbohydrate biosynthetic process
integral component of Golgi membrane
proteoglycan biosynthetic process
cellular polysaccharide metabolic process
polysaccharide metabolic process
Golgi cisterna membrane
proteoglycan metabolic process
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
carbohydrate biosynthetic process
glycosaminoglycan metabolic process
aminoglycan metabolic process
cellular carbohydrate metabolic process
sulfur compound biosynthetic process
glycoprotein biosynthetic process
sulfur compound metabolic process
glycoprotein metabolic process
carbohydrate metabolic process
Golgi membrane
carbohydrate derivative biosynthetic process
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process