CSTF2

Entrez Summary: This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008].
UniProt Summary: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity). {ECO:0000250, ECO:0000269|PubMed:9199325}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 5/683

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/25
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	1/72
lymphocyte	0/14
ovary	1/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	1/1
skin	0/20
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

cleavage body
pre-mRNA cleavage required for polyadenylation
mRNA cleavage involved in mRNA processing
tRNA splicing, via endonucleolytic cleavage and ligation
RNA splicing, via endonucleolytic cleavage and ligation
mRNA cleavage and polyadenylation specificity factor complex
mRNA cleavage
mRNA polyadenylation
RNA polyadenylation
termination of RNA polymerase II transcription
DNA-templated transcription, termination
mRNA 3-end processing
tRNA processing
RNA 3-end processing
RNA phosphodiester bond hydrolysis
mRNA binding
tRNA metabolic process
nuclear body
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
nucleic acid phosphodiester bond hydrolysis
RNA splicing, via transesterification reactions
ncRNA processing
RNA splicing
ncRNA metabolic process
mRNA processing
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
mRNA metabolic process
RNA processing
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
RNA binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process