CTHRC1 [The Human Chemical-Genetic Interaction Map Project]

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======= CTHRC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTHRC1
  * **<color #00a2e8>Official Name</color>**: collagen triple helix repeat containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=115908|115908]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96CG8|Q96CG8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTHRC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTHRC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610635|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a negative regulator of collagen matrix deposition. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Collagen|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|establishment of planar polarity involved in neural tube closure|
|establishment of planar polarity of embryonic epithelium|
|ossification involved in bone remodeling|
|positive regulation of osteoblast proliferation|
|regulation of osteoblast proliferation|
|establishment of tissue polarity|
|establishment of planar polarity|
|cochlea morphogenesis|
|inner ear receptor cell stereocilium organization|
|Wnt-protein binding|
|frizzled binding|
|inner ear receptor cell development|
|morphogenesis of a polarized epithelium|
|bone remodeling|
|cochlea development|
|inner ear receptor cell differentiation|
|mechanoreceptor differentiation|
|positive regulation of osteoblast differentiation|
|collagen trimer|
|positive regulation of ossification|
|neural tube closure|
|tube closure|
|positive regulation of protein binding|
|Wnt signaling pathway, planar cell polarity pathway|
|inner ear morphogenesis|
|primary neural tube formation|
|tissue remodeling|
|neural tube formation|
|regulation of establishment of planar polarity|
|regulation of osteoblast differentiation|
|ear morphogenesis|
|embryonic epithelial tube formation|
|epithelial tube formation|
|extracellular matrix structural constituent|
|non-canonical Wnt signaling pathway|
|morphogenesis of embryonic epithelium|
|tube formation|
|neural tube development|
|negative regulation of canonical Wnt signaling pathway|
|positive regulation of binding|
|regulation of morphogenesis of an epithelium|
|regulation of ossification|
|inner ear development|
|negative regulation of Wnt signaling pathway|
|regulation of protein binding|
|ear development|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|ossification|
|regulation of canonical Wnt signaling pathway|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|collagen-containing extracellular matrix|
|regulation of binding|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|embryonic organ development|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|neuron projection development|
|neuron development|
|tube development|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|generation of neurons|
|movement of cell or subcellular component|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of cell differentiation|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8360
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTHRC1 Expression in NALM6 Cells: 3.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>