CTHRC1

Entrez Summary: This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012].
UniProt Summary: May act as a negative regulator of collagen matrix deposition. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

establishment of planar polarity involved in neural tube closure
establishment of planar polarity of embryonic epithelium
ossification involved in bone remodeling
positive regulation of osteoblast proliferation
regulation of osteoblast proliferation
establishment of tissue polarity
establishment of planar polarity
cochlea morphogenesis
inner ear receptor cell stereocilium organization
Wnt-protein binding
frizzled binding
inner ear receptor cell development
morphogenesis of a polarized epithelium
bone remodeling
cochlea development
inner ear receptor cell differentiation
mechanoreceptor differentiation
positive regulation of osteoblast differentiation
collagen trimer
positive regulation of ossification
neural tube closure
tube closure
positive regulation of protein binding
Wnt signaling pathway, planar cell polarity pathway
inner ear morphogenesis
primary neural tube formation
tissue remodeling
neural tube formation
regulation of establishment of planar polarity
regulation of osteoblast differentiation
ear morphogenesis
embryonic epithelial tube formation
epithelial tube formation
extracellular matrix structural constituent
non-canonical Wnt signaling pathway
morphogenesis of embryonic epithelium
tube formation
neural tube development
negative regulation of canonical Wnt signaling pathway
positive regulation of binding