CTLA4

Gene Information

Official Symbol: CTLA4
Official Name: cytotoxic T-lymphocyte associated protein 4
Aliases and Previous Symbols: N/A
Entrez ID: 1493
UniProt: P16410
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16391
Expression level (log2 read counts): -2.64

Expression Distribution

protein complex involved in cell adhesion
negative regulation of regulatory T cell differentiation
negative regulation of B cell proliferation
clathrin-coated endocytic vesicle
negative regulation of B cell activation
regulation of regulatory T cell differentiation
negative regulation of T cell differentiation
negative regulation of lymphocyte differentiation
T cell costimulation
lymphocyte costimulation
negative regulation of T cell proliferation
regulation of B cell proliferation
negative regulation of lymphocyte proliferation
negative regulation of mononuclear cell proliferation
negative regulation of leukocyte proliferation
negative regulation of leukocyte differentiation
negative regulation of T cell activation
negative regulation of leukocyte cell-cell adhesion
B cell receptor signaling pathway
negative regulation of hemopoiesis
regulation of T cell differentiation
negative regulation of lymphocyte activation
negative regulation of immune response
regulation of T cell proliferation
regulation of lymphocyte differentiation
negative regulation of leukocyte activation
negative regulation of cell-cell adhesion
T cell receptor signaling pathway
negative regulation of cell activation
positive regulation of T cell activation
regulation of B cell activation
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
positive regulation of leukocyte cell-cell adhesion
regulation of leukocyte proliferation
positive regulation of cell-cell adhesion
negative regulation of cell adhesion
regulation of leukocyte differentiation
antigen receptor-mediated signaling pathway
regulation of leukocyte cell-cell adhesion