CTNNBIP1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= CTNNBIP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTNNBIP1
  * **<color #00a2e8>Official Name</color>**: catenin beta interacting protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56998|56998]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NSA3|Q9NSA3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTNNBIP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTNNBIP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607758|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. {ECO:0000269|PubMed:12408824}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ICAT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of vascular permeability involved in acute inflammatory response|
|negative regulation of transcription initiation from RNA polymerase II promoter|
|negative regulation of DNA-templated transcription, initiation|
|negative regulation of mesenchymal cell proliferation|
|positive regulation of monocyte differentiation|
|armadillo repeat domain binding|
|beta-catenin destruction complex|
|regulation of monocyte differentiation|
|regulation of transcription initiation from RNA polymerase II promoter|
|regulation of mesenchymal cell proliferation|
|regulation of DNA-templated transcription, initiation|
|regulation of vascular permeability|
|branching involved in ureteric bud morphogenesis|
|negative regulation of smooth muscle cell proliferation|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|negative regulation of DNA binding|
|positive regulation of myeloid leukocyte differentiation|
|positive regulation of osteoblast differentiation|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|renal tubule morphogenesis|
|acute inflammatory response|
|nephron tubule development|
|renal tubule development|
|beta-catenin binding|
|kidney morphogenesis|
|positive regulation of ossification|
|ureteric bud development|
|mesonephric epithelium development|
|mesonephric tubule development|
|mesonephros development|
|positive regulation of myeloid cell differentiation|
|nephron epithelium development|
|negative regulation of protein binding|
|regulation of osteoblast differentiation|
|regulation of myeloid leukocyte differentiation|
|nephron development|
|regulation of DNA binding|
|kidney epithelium development|
|negative regulation of protein complex assembly|
|branching morphogenesis of an epithelial tube|
|regulation of smooth muscle cell proliferation|
|positive regulation of leukocyte differentiation|
|morphogenesis of a branching epithelium|
|negative regulation of DNA-binding transcription factor activity|
|morphogenesis of a branching structure|
|vascular process in circulatory system|
|negative regulation of binding|
|positive regulation of hemopoiesis|
|regulation of ossification|
|negative regulation of Wnt signaling pathway|
|anterior/posterior pattern specification|
|regulation of protein binding|
|regulation of myeloid cell differentiation|
|kidney development|
|regulation of leukocyte differentiation|
|renal system development|
|epithelial tube morphogenesis|
|urogenital system development|
|regionalization|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|regulation of binding|
|blood circulation|
|circulatory system process|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of DNA-binding transcription factor activity|
|morphogenesis of an epithelium|
|pattern specification process|
|regulation of protein complex assembly|
|regulation of hemopoiesis|
|inflammatory response|
|tissue morphogenesis|
|tube morphogenesis|
|negative regulation of cell population proliferation|
|negative regulation of cellular component organization|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|epithelium development|
|cell-cell signaling|
|negative regulation of molecular function|
|positive regulation of immune system process|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.7|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.7|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.83|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|1.84|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.2|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|3.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:axin1|AXIN1]]|0.422|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10125
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTNNBIP1 Expression in NALM6 Cells: 1.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>