CTNNBIP1

Gene Information

Official Symbol: CTNNBIP1
Official Name: catenin beta interacting protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 56998
UniProt: Q9NSA3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. {ECO:0000269|PubMed:12408824}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ABT-702 5μM R06 exp261	-1.7
3-Bromopyruvate 7μM R04 exp175	1.7
MK-1775 0.32μM R02 exp75	1.83
Isoniazid 100μM R08 exp494	1.84
Calcium Ionophore 0.4μM R07 exp342	2.2
Lead acetate 2000μM R08 exp498 no dilution day6	3.51

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10125
Expression level (log2 read counts): 1.64

Expression Distribution

regulation of vascular permeability involved in acute inflammatory response
negative regulation of transcription initiation from RNA polymerase II promoter
negative regulation of DNA-templated transcription, initiation
negative regulation of mesenchymal cell proliferation
positive regulation of monocyte differentiation
armadillo repeat domain binding
beta-catenin destruction complex
regulation of monocyte differentiation
regulation of transcription initiation from RNA polymerase II promoter
regulation of mesenchymal cell proliferation
regulation of DNA-templated transcription, initiation
regulation of vascular permeability
branching involved in ureteric bud morphogenesis
negative regulation of smooth muscle cell proliferation
ureteric bud morphogenesis
mesonephric tubule morphogenesis
negative regulation of DNA binding
positive regulation of myeloid leukocyte differentiation
positive regulation of osteoblast differentiation
nephron tubule morphogenesis
nephron epithelium morphogenesis
nephron morphogenesis
renal tubule morphogenesis
acute inflammatory response
nephron tubule development
renal tubule development
beta-catenin binding
kidney morphogenesis
positive regulation of ossification
ureteric bud development
mesonephric epithelium development
mesonephric tubule development
mesonephros development
positive regulation of myeloid cell differentiation
nephron epithelium development
negative regulation of protein binding
regulation of osteoblast differentiation
regulation of myeloid leukocyte differentiation
nephron development
regulation of DNA binding