CTSS [The Human Chemical-Genetic Interaction Map Project]

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======= CTSS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTSS
  * **<color #00a2e8>Official Name</color>**: cathepsin S
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1520|1520]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25774|P25774]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTSS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTSS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/116845|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Inhibitor I29|
|Peptidase C1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|basement membrane disassembly|
|endolysosome lumen|
|proteoglycan binding|
|cellular response to thyroid hormone stimulus|
|basement membrane organization|
|response to acidic pH|
|laminin binding|
|response to thyroid hormone|
|fibronectin binding|
|response to pH|
|collagen catabolic process|
|tertiary granule lumen|
|collagen binding|
|extracellular matrix disassembly|
|collagen metabolic process|
|positive regulation of cation channel activity|
|cysteine-type endopeptidase activity|
|lysosomal lumen|
|toll-like receptor signaling pathway|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of transporter activity|
|ficolin-1-rich granule lumen|
|late endosome|
|pattern recognition receptor signaling pathway|
|positive regulation of cation transmembrane transport|
|positive regulation of ion transmembrane transport|
|protein processing|
|regulation of cation channel activity|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|positive regulation of transmembrane transport|
|antigen processing and presentation|
|protein maturation|
|innate immune response-activating signal transduction|
|lysosome|
|activation of innate immune response|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of cation transmembrane transport|
|extracellular matrix organization|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|collagen-containing extracellular matrix|
|extracellular structure organization|
|cellular component disassembly|
|regulation of innate immune response|
|positive regulation of defense response|
|regulation of ion transmembrane transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|regulation of response to biotic stimulus|
|myeloid cell activation involved in immune response|
|immune response-activating signal transduction|
|regulation of transmembrane transport|
|myeloid leukocyte activation|
|proteolysis involved in cellular protein catabolic process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|adaptive immune response|
|cellular protein catabolic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|protein catabolic process|
|intracellular membrane-bounded organelle|
|regulation of ion transport|
|regulated exocytosis|
|regulation of defense response|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|exocytosis|
|positive regulation of immune response|
|cellular macromolecule catabolic process|
|response to hormone|
|leukocyte activation|
|positive regulation of transport|
|secretion by cell|
|export from cell|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|proteolysis|
|response to endogenous stimulus|
|regulation of response to stress|
|extracellular space|
|regulation of immune system process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.25|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-2.02|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.96|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.73|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.81|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8421
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTSS Expression in NALM6 Cells: 6.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>