CTSS
Gene Information
- Official Symbol: CTSS
- Official Name: cathepsin S
- Aliases and Previous Symbols: N/A
- Entrez ID: 1520
- UniProt: P25774
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
Pfam Domains GO Terms
Pfam Domains
| Inhibitor I29 |
| Peptidase C1 |
GO Terms
| basement membrane disassembly |
| endolysosome lumen |
| proteoglycan binding |
| cellular response to thyroid hormone stimulus |
| basement membrane organization |
| response to acidic pH |
| laminin binding |
| response to thyroid hormone |
| fibronectin binding |
| response to pH |
| collagen catabolic process |
| tertiary granule lumen |
| collagen binding |
| extracellular matrix disassembly |
| collagen metabolic process |
| positive regulation of cation channel activity |
| cysteine-type endopeptidase activity |
| lysosomal lumen |
| toll-like receptor signaling pathway |
| antigen processing and presentation of exogenous peptide antigen via MHC class II |
| antigen processing and presentation of peptide antigen via MHC class II |
| antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| positive regulation of ion transmembrane transporter activity |
| positive regulation of transporter activity |
| ficolin-1-rich granule lumen |
| late endosome |
| pattern recognition receptor signaling pathway |
| positive regulation of cation transmembrane transport |
| positive regulation of ion transmembrane transport |
| protein processing |
| regulation of cation channel activity |
| antigen processing and presentation of exogenous peptide antigen |
| antigen processing and presentation of exogenous antigen |
| antigen processing and presentation of peptide antigen |
| positive regulation of transmembrane transport |
| antigen processing and presentation |
| protein maturation |
| innate immune response-activating signal transduction |
| lysosome |
| activation of innate immune response |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| positive regulation of ion transport |
| regulation of transporter activity |
| regulation of cation transmembrane transport |
| extracellular matrix organization |
| positive regulation of innate immune response |
| positive regulation of response to biotic stimulus |
| collagen-containing extracellular matrix |
| extracellular structure organization |
| cellular component disassembly |
| regulation of innate immune response |
| positive regulation of defense response |
| regulation of ion transmembrane transport |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| positive regulation of multi-organism process |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| regulation of response to biotic stimulus |
| myeloid cell activation involved in immune response |
| immune response-activating signal transduction |
| regulation of transmembrane transport |
| myeloid leukocyte activation |
| proteolysis involved in cellular protein catabolic process |
| immune response-regulating signaling pathway |
| positive regulation of response to external stimulus |
| cellular response to hormone stimulus |
| adaptive immune response |
| cellular protein catabolic process |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| activation of immune response |
| protein catabolic process |
| intracellular membrane-bounded organelle |
| regulation of ion transport |
| regulated exocytosis |
| regulation of defense response |
| leukocyte mediated immunity |
| regulation of multi-organism process |
| exocytosis |
| positive regulation of immune response |
| cellular macromolecule catabolic process |
| response to hormone |
| leukocyte activation |
| positive regulation of transport |
| secretion by cell |
| export from cell |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| cell activation |
| immune effector process |
| regulation of response to external stimulus |
| secretion |
| regulation of immune response |
| positive regulation of immune system process |
| response to abiotic stimulus |
| cellular response to endogenous stimulus |
| proteolysis |
| response to endogenous stimulus |
| regulation of response to stress |
| extracellular space |
| regulation of immune system process |
| organic substance catabolic process |
| positive regulation of molecular function |
| cellular catabolic process |
| regulation of transport |
| immune response |
| extracellular region |
| vesicle-mediated transport |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8421
- Expression level (log2 read counts): 6.37
Expression Distribution
CTSS Expression in NALM6 Cells: 6.37
