CTSZ [The Human Chemical-Genetic Interaction Map Project]

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======= CTSZ =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTSZ
  * **<color #00a2e8>Official Name</color>**: cathepsin Z
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1522|1522]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBR2|Q9UBR2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTSZ&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTSZ|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603169|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Exhibits carboxy-monopeptidase as well as carboxy- dipeptidase activity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase C1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of plasminogen activation|
|regulation of angiotensin levels in blood|
|angiotensin maturation|
|cell cortex region|
|regulation of plasminogen activation|
|regulation of systemic arterial blood pressure by circulatory renin-angiotensin|
|carboxypeptidase activity|
|regulation of systemic arterial blood pressure by renin-angiotensin|
|epithelial tube branching involved in lung morphogenesis|
|cysteine-type peptidase activity|
|negative regulation of protein processing|
|negative regulation of protein maturation|
|peptide hormone processing|
|regulation of systemic arterial blood pressure by hormone|
|COPII-coated ER to Golgi transport vesicle|
|lung morphogenesis|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|endocrine process|
|positive regulation of neural precursor cell proliferation|
|positive regulation of neuron apoptotic process|
|specific granule lumen|
|COPII vesicle coating|
|vesicle targeting, rough ER to cis-Golgi|
|regulation of protein processing|
|vesicle coating|
|regulation of protein maturation|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|Golgi vesicle budding|
|regulation of neural precursor cell proliferation|
|vesicle targeting|
|positive regulation of neuron death|
|cysteine-type endopeptidase activity|
|regulation of systemic arterial blood pressure|
|vesicle budding from membrane|
|negative regulation of protein binding|
|ficolin-1-rich granule lumen|
|growth cone|
|branching morphogenesis of an epithelial tube|
|negative regulation of neuron projection development|
|protein processing|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|lung development|
|negative regulation of binding|
|respiratory tube development|
|establishment of vesicle localization|
|negative regulation of cell projection organization|
|regulation of blood pressure|
|vesicle localization|
|respiratory system development|
|hormone metabolic process|
|regulation of neuron apoptotic process|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|regulation of protein binding|
|negative regulation of neuron differentiation|
|protein maturation|
|lysosome|
|cytoplasmic vesicle|
|negative regulation of neurogenesis|
|vesicle organization|
|endoplasmic reticulum lumen|
|epithelial tube morphogenesis|
|regulation of neuron death|
|negative regulation of nervous system development|
|negative regulation of cell development|
|negative regulation of proteolysis|
|establishment of organelle localization|
|collagen-containing extracellular matrix|
|Golgi vesicle transport|
|regulation of binding|
|blood circulation|
|circulatory system process|
|morphogenesis of an epithelium|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of neuron projection development|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|peptide metabolic process|
|regulation of hormone levels|
|tissue morphogenesis|
|organelle localization|
|myeloid leukocyte activation|
|proteolysis involved in cellular protein catabolic process|
|cell surface|
|cellular protein catabolic process|
|Golgi membrane|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|tube morphogenesis|
|regulation of neuron differentiation|
|protein catabolic process|
|intracellular membrane-bounded organelle|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulated exocytosis|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of proteolysis|
|leukocyte mediated immunity|
|cellular amide metabolic process|
|exocytosis|
|regulation of neurogenesis|
|tube development|
|membrane organization|
|cellular macromolecule catabolic process|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|secretion by cell|
|endoplasmic reticulum|
|negative regulation of cellular protein metabolic process|
|export from cell|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cell activation|
|immune effector process|
|negative regulation of protein metabolic process|
|epithelium development|
|secretion|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|proteolysis|
|intracellular transport|
|generation of neurons|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|extracellular space|
|regulation of cell population proliferation|
|neurogenesis|
|regulation of cell death|
|negative regulation of gene expression|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13281
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTSZ Expression in NALM6 Cells: 0.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>