CTSZ
Gene Information
- Official Symbol: CTSZ
- Official Name: cathepsin Z
- Aliases and Previous Symbols: N/A
- Entrez ID: 1522
- UniProt: Q9UBR2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008].
- UniProt Summary: Exhibits carboxy-monopeptidase as well as carboxy- dipeptidase activity.
Pfam Domains GO Terms
Pfam Domains
| Peptidase C1 |
GO Terms
| negative regulation of plasminogen activation |
| regulation of angiotensin levels in blood |
| angiotensin maturation |
| cell cortex region |
| regulation of plasminogen activation |
| regulation of systemic arterial blood pressure by circulatory renin-angiotensin |
| carboxypeptidase activity |
| regulation of systemic arterial blood pressure by renin-angiotensin |
| epithelial tube branching involved in lung morphogenesis |
| cysteine-type peptidase activity |
| negative regulation of protein processing |
| negative regulation of protein maturation |
| peptide hormone processing |
| regulation of systemic arterial blood pressure by hormone |
| COPII-coated ER to Golgi transport vesicle |
| lung morphogenesis |
| regulation of systemic arterial blood pressure mediated by a chemical signal |
| endocrine process |
| positive regulation of neural precursor cell proliferation |
| positive regulation of neuron apoptotic process |
| specific granule lumen |
| COPII vesicle coating |
| vesicle targeting, rough ER to cis-Golgi |
| regulation of protein processing |
| vesicle coating |
| regulation of protein maturation |
| COPII-coated vesicle budding |
| vesicle targeting, to, from or within Golgi |
| endoplasmic reticulum-Golgi intermediate compartment membrane |
| Golgi vesicle budding |
| regulation of neural precursor cell proliferation |
| vesicle targeting |
| positive regulation of neuron death |
| cysteine-type endopeptidase activity |
| regulation of systemic arterial blood pressure |
| vesicle budding from membrane |
| negative regulation of protein binding |
| ficolin-1-rich granule lumen |
| growth cone |
| branching morphogenesis of an epithelial tube |
| negative regulation of neuron projection development |
| protein processing |
| morphogenesis of a branching epithelium |
| morphogenesis of a branching structure |
| lung development |
| negative regulation of binding |
| respiratory tube development |
| establishment of vesicle localization |
| negative regulation of cell projection organization |
| regulation of blood pressure |
| vesicle localization |
| respiratory system development |
| hormone metabolic process |
| regulation of neuron apoptotic process |
| endoplasmic reticulum to Golgi vesicle-mediated transport |
| regulation of protein binding |
| negative regulation of neuron differentiation |
| protein maturation |
| lysosome |
| cytoplasmic vesicle |
| negative regulation of neurogenesis |
| vesicle organization |
| endoplasmic reticulum lumen |
| epithelial tube morphogenesis |
| regulation of neuron death |
| negative regulation of nervous system development |
| negative regulation of cell development |
| negative regulation of proteolysis |
| establishment of organelle localization |
| collagen-containing extracellular matrix |
| Golgi vesicle transport |
| regulation of binding |
| blood circulation |
| circulatory system process |
| morphogenesis of an epithelium |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| regulation of neuron projection development |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| peptide metabolic process |
| regulation of hormone levels |
| tissue morphogenesis |
| organelle localization |
| myeloid leukocyte activation |
| proteolysis involved in cellular protein catabolic process |
| cell surface |
| cellular protein catabolic process |
| Golgi membrane |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| tube morphogenesis |
| regulation of neuron differentiation |
| protein catabolic process |
| intracellular membrane-bounded organelle |
| regulation of plasma membrane bounded cell projection organization |
| positive regulation of cell death |
| regulated exocytosis |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| regulation of proteolysis |
| leukocyte mediated immunity |
| cellular amide metabolic process |
| exocytosis |
| regulation of neurogenesis |
| tube development |
| membrane organization |
| cellular macromolecule catabolic process |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| leukocyte activation |
| regulation of cell development |
| negative regulation of developmental process |
| animal organ morphogenesis |
| secretion by cell |
| endoplasmic reticulum |
| negative regulation of cellular protein metabolic process |
| export from cell |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| cell activation |
| immune effector process |
| negative regulation of protein metabolic process |
| epithelium development |
| secretion |
| negative regulation of molecular function |
| negative regulation of multicellular organismal process |
| proteolysis |
| intracellular transport |
| generation of neurons |
| regulation of apoptotic process |
| protein-containing complex assembly |
| regulation of programmed cell death |
| extracellular space |
| regulation of cell population proliferation |
| neurogenesis |
| regulation of cell death |
| negative regulation of gene expression |
| tissue development |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| establishment of localization in cell |
| protein-containing complex subunit organization |
| immune response |
| extracellular region |
| vesicle-mediated transport |
| system process |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13281
- Expression level (log2 read counts): 0.8
Expression Distribution
CTSZ Expression in NALM6 Cells: 0.8
