CXCL13 [The Human Chemical-Genetic Interaction Map Project]

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======= CXCL13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CXCL13
  * **<color #00a2e8>Official Name</color>**: C-X-C motif chemokine ligand 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10563|10563]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43927|O43927]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CXCL13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CXCL13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605149|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B- lymphocytes. Binds to BLR1/CXCR5.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CXCR5 chemokine receptor binding|
|endothelial cell chemotaxis to fibroblast growth factor|
|cell chemotaxis to fibroblast growth factor|
|negative regulation of cell chemotaxis to fibroblast growth factor|
|lymphocyte chemotaxis across high endothelial venule|
|negative regulation of endothelial cell chemotaxis to fibroblast growth factor|
|CCR10 chemokine receptor binding|
|negative regulation of endothelial cell chemotaxis|
|CXCR3 chemokine receptor binding|
|positive regulation of cell-cell adhesion mediated by integrin|
|B cell chemotaxis|
|regulation of cell chemotaxis to fibroblast growth factor|
|regulation of endothelial cell chemotaxis to fibroblast growth factor|
|positive regulation of integrin activation|
|germinal center formation|
|endothelial cell chemotaxis|
|chronic inflammatory response|
|regulation of cell-cell adhesion mediated by integrin|
|regulation of integrin activation|
|positive regulation of T cell chemotaxis|
|regulation of T cell chemotaxis|
|positive regulation of cell adhesion mediated by integrin|
|regulation of endothelial cell chemotaxis|
|positive regulation of lymphocyte chemotaxis|
|fibroblast growth factor binding|
|regulation of lymphocyte chemotaxis|
|positive regulation of T cell migration|
|receptor ligand activity|
|positive regulation of lymphocyte migration|
|regulation of T cell migration|
|regulation of cell adhesion mediated by integrin|
|lymphocyte chemotaxis|
|negative regulation of endothelial cell migration|
|chemokine activity|
|negative regulation of chemotaxis|
|regulation of lymphocyte migration|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|endothelial cell migration|
|negative regulation of epithelial cell migration|
|lymphocyte migration|
|chemokine-mediated signaling pathway|
|cell|
|neutrophil chemotaxis|
|epithelial cell migration|
|epithelium migration|
|positive regulation of leukocyte chemotaxis|
|granulocyte chemotaxis|
|cellular response to chemokine|
|response to chemokine|
|neutrophil migration|
|tissue migration|
|activation of GTPase activity|
|granulocyte migration|
|cellular response to fibroblast growth factor stimulus|
|antimicrobial humoral response|
|regulation of leukocyte chemotaxis|
|response to fibroblast growth factor|
|myeloid leukocyte migration|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|regulation of humoral immune response|
|leukocyte chemotaxis|
|negative regulation of cellular response to growth factor stimulus|
|regulation of endothelial cell migration|
|heparin binding|
|ameboidal-type cell migration|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|regulation of leukocyte migration|
|cell chemotaxis|
|regulation of chemotaxis|
|cellular response to biotic stimulus|
|regulation of epithelial cell migration|
|positive regulation of protein complex assembly|
|positive regulation of cell-cell adhesion|
|negative regulation of cell migration|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell motility|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of cytosolic calcium ion concentration|
|regulation of angiogenesis|
|negative regulation of cellular component movement|
|response to lipopolysaccharide|
|regulation of vasculature development|
|negative regulation of locomotion|
|response to molecule of bacterial origin|
|regulation of cytosolic calcium ion concentration|
|defense response to bacterium|
|humoral immune response|
|negative regulation of response to external stimulus|
|leukocyte migration|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of GTPase activity|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|regulation of protein complex assembly|
|cellular divalent inorganic cation homeostasis|
|regulation of GTPase activity|
|protein heterodimerization activity|
|divalent inorganic cation homeostasis|
|inflammatory response|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|cellular response to lipid|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of cellular component movement|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|positive regulation of response to external stimulus|
|adaptive immune response|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|response to bacterium|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|ion homeostasis|
|regulation of cell migration|
|response to lipid|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|regulation of cell motility|
|defense response to other organism|
|regulation of cellular component biogenesis|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|response to cytokine|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|extracellular space|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|positive regulation of molecular function|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16911
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CXCL13 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>