CXCL13
Gene Information
- Official Symbol: CXCL13
- Official Name: C-X-C motif chemokine ligand 13
- Aliases and Previous Symbols: N/A
- Entrez ID: 10563
- UniProt: O43927
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B- lymphocytes. Binds to BLR1/CXCR5.
Pfam Domains GO Terms
Pfam Domains
| IL8 |
GO Terms
| CXCR5 chemokine receptor binding |
| endothelial cell chemotaxis to fibroblast growth factor |
| cell chemotaxis to fibroblast growth factor |
| negative regulation of cell chemotaxis to fibroblast growth factor |
| lymphocyte chemotaxis across high endothelial venule |
| negative regulation of endothelial cell chemotaxis to fibroblast growth factor |
| CCR10 chemokine receptor binding |
| negative regulation of endothelial cell chemotaxis |
| CXCR3 chemokine receptor binding |
| positive regulation of cell-cell adhesion mediated by integrin |
| B cell chemotaxis |
| regulation of cell chemotaxis to fibroblast growth factor |
| regulation of endothelial cell chemotaxis to fibroblast growth factor |
| positive regulation of integrin activation |
| germinal center formation |
| endothelial cell chemotaxis |
| chronic inflammatory response |
| regulation of cell-cell adhesion mediated by integrin |
| regulation of integrin activation |
| positive regulation of T cell chemotaxis |
| regulation of T cell chemotaxis |
| positive regulation of cell adhesion mediated by integrin |
| regulation of endothelial cell chemotaxis |
| positive regulation of lymphocyte chemotaxis |
| fibroblast growth factor binding |
| regulation of lymphocyte chemotaxis |
| positive regulation of T cell migration |
| receptor ligand activity |
| positive regulation of lymphocyte migration |
| regulation of T cell migration |
| regulation of cell adhesion mediated by integrin |
| lymphocyte chemotaxis |
| negative regulation of endothelial cell migration |
| chemokine activity |
| negative regulation of chemotaxis |
| regulation of lymphocyte migration |
| antimicrobial humoral immune response mediated by antimicrobial peptide |
| endothelial cell migration |
| negative regulation of epithelial cell migration |
| lymphocyte migration |
| chemokine-mediated signaling pathway |
| cell |
| neutrophil chemotaxis |
| epithelial cell migration |
| epithelium migration |
| positive regulation of leukocyte chemotaxis |
| granulocyte chemotaxis |
| cellular response to chemokine |
| response to chemokine |
| neutrophil migration |
| tissue migration |
| activation of GTPase activity |
| granulocyte migration |
| cellular response to fibroblast growth factor stimulus |
| antimicrobial humoral response |
| regulation of leukocyte chemotaxis |
| response to fibroblast growth factor |
| myeloid leukocyte migration |
| positive regulation of leukocyte migration |
| positive regulation of chemotaxis |
| regulation of humoral immune response |
| leukocyte chemotaxis |
| negative regulation of cellular response to growth factor stimulus |
| regulation of endothelial cell migration |
| heparin binding |
| ameboidal-type cell migration |
| cellular response to lipopolysaccharide |
| cellular response to molecule of bacterial origin |
| regulation of leukocyte migration |
| cell chemotaxis |
| regulation of chemotaxis |
| cellular response to biotic stimulus |
| regulation of epithelial cell migration |
| positive regulation of protein complex assembly |
| positive regulation of cell-cell adhesion |
| negative regulation of cell migration |
| regulation of cellular response to growth factor stimulus |
| negative regulation of cell motility |
| adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| positive regulation of cytosolic calcium ion concentration |
| regulation of angiogenesis |
| negative regulation of cellular component movement |
| response to lipopolysaccharide |
| regulation of vasculature development |
| negative regulation of locomotion |
| response to molecule of bacterial origin |
| regulation of cytosolic calcium ion concentration |
| defense response to bacterium |
| humoral immune response |
| negative regulation of response to external stimulus |
| leukocyte migration |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of GTPase activity |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| regulation of protein complex assembly |
| cellular divalent inorganic cation homeostasis |
| regulation of GTPase activity |
| protein heterodimerization activity |
| divalent inorganic cation homeostasis |
| inflammatory response |
| cellular response to growth factor stimulus |
| positive regulation of cell migration |
| cellular response to lipid |
| positive regulation of cellular component biogenesis |
| positive regulation of cell motility |
| response to growth factor |
| positive regulation of cellular component movement |
| chemotaxis |
| taxis |
| positive regulation of locomotion |
| cellular metal ion homeostasis |
| positive regulation of response to external stimulus |
| adaptive immune response |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| response to bacterium |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| positive regulation of hydrolase activity |
| ion homeostasis |
| regulation of cell migration |
| response to lipid |
| anatomical structure formation involved in morphogenesis |
| cellular homeostasis |
| regulation of cell motility |
| defense response to other organism |
| regulation of cellular component biogenesis |
| cell migration |
| regulation of locomotion |
| regulation of cellular component movement |
| cellular response to cytokine stimulus |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| localization of cell |
| cell motility |
| regulation of response to external stimulus |
| response to cytokine |
| chemical homeostasis |
| cell-cell signaling |
| positive regulation of immune system process |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| defense response |
| positive regulation of catalytic activity |
| response to endogenous stimulus |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| extracellular space |
| negative regulation of response to stimulus |
| homeostatic process |
| regulation of immune system process |
| positive regulation of molecular function |
| immune response |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16911
- Expression level (log2 read counts): -6.6
Expression Distribution
CXCL13 Expression in NALM6 Cells: -6.6
