CXCL14

Entrez Summary: N/A
UniProt Summary: Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays. {ECO:0000269|PubMed:10049774, ECO:0000269|PubMed:10946286}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Vinblastine 0.2μM R03 exp108	-1.84
Rotenone 0.07μM R08 exp431	-1.75

positive regulation of natural killer cell chemotaxis
regulation of natural killer cell chemotaxis
positive regulation of lymphocyte chemotaxis
negative regulation of myoblast differentiation
regulation of lymphocyte chemotaxis
positive regulation of lymphocyte migration
chemokine activity
regulation of myoblast differentiation
regulation of lymphocyte migration
positive regulation of leukocyte chemotaxis
regulation of leukocyte chemotaxis
positive regulation of leukocyte migration
positive regulation of chemotaxis
inner ear development
regulation of leukocyte migration
cell chemotaxis
regulation of chemotaxis
ear development
positive regulation of cell migration
positive regulation of cell motility
positive regulation of cellular component movement
sensory organ development
chemotaxis
taxis
positive regulation of locomotion
positive regulation of response to external stimulus
negative regulation of cell differentiation
regulation of cell migration
regulation of cell motility
negative regulation of developmental process
cell migration
regulation of locomotion
Golgi apparatus
regulation of cellular component movement
cell motility
localization of cell
regulation of response to external stimulus
cell-cell signaling
positive regulation of immune system process
locomotion