CXCR5

Entrez Summary: N/A
UniProt Summary: Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

7TM GPCR Srsx
7tm 1

C-X-C chemokine receptor activity
lymph node development
C-C chemokine receptor activity
chemokine binding
C-C chemokine binding
positive regulation of cytokinesis
chemokine-mediated signaling pathway
positive regulation of cell division
regulation of cytokinesis
response to chemokine
cellular response to chemokine
leukocyte chemotaxis
calcium-mediated signaling
B cell activation
regulation of cell division
cell chemotaxis
positive regulation of cytosolic calcium ion concentration
positive regulation of cell cycle process
regulation of cytosolic calcium ion concentration
second-messenger-mediated signaling
positive regulation of cell cycle
leukocyte migration
lymphocyte activation
external side of plasma membrane
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
chemotaxis
taxis
cellular metal ion homeostasis
hematopoietic or lymphoid organ development
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
immune system development
cytokine-mediated signaling pathway
cation homeostasis
inorganic ion homeostasis
G protein-coupled receptor activity