CYP11B2 [The Human Chemical-Genetic Interaction Map Project]

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======= CYP11B2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYP11B2
  * **<color #00a2e8>Official Name</color>**: cytochrome P450 family 11 subfamily B member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1585|1585]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19099|P19099]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYP11B2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYP11B2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/124080|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Preferentially catalyzes the conversion of 11- deoxycorticosterone to aldosterone via corticosterone and 18- hydroxycorticosterone. {ECO:0000269|PubMed:23322723}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|p450|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|corticosterone 18-monooxygenase activity|
|regulation of blood volume by renal aldosterone|
|steroid 11-beta-monooxygenase activity|
|aldosterone biosynthetic process|
|tertiary alcohol biosynthetic process|
|cortisol biosynthetic process|
|aldosterone metabolic process|
|cortisol metabolic process|
|primary alcohol biosynthetic process|
|mineralocorticoid biosynthetic process|
|mineralocorticoid metabolic process|
|aldehyde biosynthetic process|
|cellular response to potassium ion|
|glucocorticoid biosynthetic process|
|tertiary alcohol metabolic process|
|positive regulation of systemic arterial blood pressure|
|response to potassium ion|
|C21-steroid hormone biosynthetic process|
|glucocorticoid metabolic process|
|renal system process involved in regulation of blood volume|
|renal system process involved in regulation of systemic arterial blood pressure|
|C21-steroid hormone metabolic process|
|ketone biosynthetic process|
|potassium ion homeostasis|
|sodium ion homeostasis|
|steroid hydroxylase activity|
|renal water homeostasis|
|positive regulation of blood pressure|
|regulation of systemic arterial blood pressure by hormone|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|steroid hormone biosynthetic process|
|endocrine process|
|cellular aldehyde metabolic process|
|hormone biosynthetic process|
|multicellular organismal water homeostasis|
|cellular ketone metabolic process|
|water homeostasis|
|primary alcohol metabolic process|
|regulation of systemic arterial blood pressure|
|renal system process|
|alcohol biosynthetic process|
|cholesterol metabolic process|
|cellular hormone metabolic process|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|iron ion binding|
|sterol metabolic process|
|monovalent inorganic cation homeostasis|
|heme binding|
|regulation of blood pressure|
|organic hydroxy compound biosynthetic process|
|cellular response to metal ion|
|hormone metabolic process|
|cellular response to inorganic substance|
|steroid metabolic process|
|cellular response to peptide hormone stimulus|
|alcohol metabolic process|
|multicellular organismal homeostasis|
|cellular response to peptide|
|response to metal ion|
|blood circulation|
|response to peptide hormone|
|mitochondrial inner membrane|
|circulatory system process|
|organic hydroxy compound metabolic process|
|response to peptide|
|regulation of body fluid levels|
|drug metabolic process|
|response to inorganic substance|
|regulation of hormone levels|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|metal ion homeostasis|
|cellular response to nitrogen compound|
|cation homeostasis|
|inorganic ion homeostasis|
|ion homeostasis|
|response to hormone|
|oxidation-reduction process|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|homeostatic process|
|small molecule metabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14432
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYP11B2 Expression in NALM6 Cells: -4.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>