CYP11B2

Entrez Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq, Jul 2008].
UniProt Summary: Preferentially catalyzes the conversion of 11- deoxycorticosterone to aldosterone via corticosterone and 18- hydroxycorticosterone. {ECO:0000269|PubMed:23322723}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

corticosterone 18-monooxygenase activity
regulation of blood volume by renal aldosterone
steroid 11-beta-monooxygenase activity
aldosterone biosynthetic process
tertiary alcohol biosynthetic process
cortisol biosynthetic process
aldosterone metabolic process
cortisol metabolic process
primary alcohol biosynthetic process
mineralocorticoid biosynthetic process
mineralocorticoid metabolic process
aldehyde biosynthetic process
cellular response to potassium ion
glucocorticoid biosynthetic process
tertiary alcohol metabolic process
positive regulation of systemic arterial blood pressure
response to potassium ion
C21-steroid hormone biosynthetic process
glucocorticoid metabolic process
renal system process involved in regulation of blood volume
renal system process involved in regulation of systemic arterial blood pressure
C21-steroid hormone metabolic process
ketone biosynthetic process
potassium ion homeostasis
sodium ion homeostasis
steroid hydroxylase activity
renal water homeostasis
positive regulation of blood pressure
regulation of systemic arterial blood pressure by hormone
regulation of systemic arterial blood pressure mediated by a chemical signal
steroid hormone biosynthetic process
endocrine process
cellular aldehyde metabolic process
hormone biosynthetic process
multicellular organismal water homeostasis
cellular ketone metabolic process
water homeostasis
primary alcohol metabolic process
regulation of systemic arterial blood pressure
renal system process