CYP19A1

• Official Symbol: CYP19A1
• Official Name: cytochrome P450 family 19 subfamily A member 1
• Aliases and Previous Symbols: N/A
• Entrez ID: 1588
• UniProt: P11511
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016].
• UniProt Summary: Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 4951
• Expression level (log2 read counts): -1.34

Expression Distribution

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CYP19A1 Expression in NALM6 Cells: -1.34