CYP26C1

Entrez Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues. This gene is adjacent to a related gene on chromosome 10q23.33. [provided by RefSeq, Jul 2008].
UniProt Summary: Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate).

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

retinoic acid catabolic process
diterpenoid catabolic process
terpenoid catabolic process
fat-soluble vitamin catabolic process
negative regulation of retinoic acid receptor signaling pathway
isoprenoid catabolic process
retinoic acid 4-hydroxylase activity
vitamin catabolic process
regulation of retinoic acid receptor signaling pathway
retinoic acid binding
retinoic acid metabolic process
fat-soluble vitamin metabolic process
neural crest cell development
stem cell development
mesenchymal cell development
neural crest cell differentiation
organelle fusion
retinoid metabolic process
diterpenoid metabolic process
monocarboxylic acid catabolic process
terpenoid metabolic process
cellular hormone metabolic process
vitamin metabolic process
iron ion binding
sterol metabolic process
isoprenoid metabolic process
heme binding
mesenchymal cell differentiation
stem cell differentiation
cellular lipid catabolic process
hormone metabolic process
anterior/posterior pattern specification
mesenchyme development
steroid metabolic process
organic acid catabolic process
carboxylic acid catabolic process
lipid catabolic process
regionalization
pattern specification process
small molecule catabolic process