CYP27C1

Entrez Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the conversion of all-trans retinol (also called vitamin A1, the precursor of 11-cis retinal) to 3,4- didehydroretinol (also called vitamin A2, the precursor of 11-cis 3,4-didehydroretinal). Also acts on all-trans retinal and all- trans retinoic acid. {ECO:0000269|PubMed:27059013}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

all-trans retinal 3,4-desaturase activity
all-trans retinoic acid 3,4-desaturase activity
all-trans retinol 3,4-desaturase activity
11-cis-retinal 3,4-desaturase activity
all-trans retinal binding
all-trans-retinol binding
11-cis retinal binding
retinal metabolic process
retinoic acid binding
retinoic acid metabolic process
monooxygenase activity
retinol metabolic process
cellular aldehyde metabolic process
primary alcohol metabolic process
retinoid metabolic process
diterpenoid metabolic process
terpenoid metabolic process
cellular hormone metabolic process
iron ion binding
isoprenoid metabolic process
heme binding
hormone metabolic process
alcohol metabolic process
organic hydroxy compound metabolic process
monocarboxylic acid metabolic process
regulation of hormone levels
intracellular membrane-bounded organelle
carboxylic acid metabolic process
cellular lipid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
lipid metabolic process
small molecule metabolic process
membrane