CYP2C19

Entrez Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008].
UniProt Summary: Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

monoterpenoid metabolic process
omega-hydroxylase P450 pathway
arachidonic acid epoxygenase activity
epoxygenase P450 pathway
exogenous drug catabolic process
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
monooxygenase activity
oxygen binding
steroid hydroxylase activity
arachidonic acid metabolic process
unsaturated fatty acid metabolic process
icosanoid metabolic process
long-chain fatty acid metabolic process
oxidoreductase activity
terpenoid metabolic process
xenobiotic metabolic process
iron ion binding
isoprenoid metabolic process
heme binding
drug catabolic process
fatty acid derivative metabolic process
cellular response to xenobiotic stimulus
steroid metabolic process
response to xenobiotic stimulus
fatty acid metabolic process
enzyme binding
drug metabolic process
monocarboxylic acid metabolic process
intracellular membrane-bounded organelle
carboxylic acid metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
oxidation-reduction process
oxoacid metabolic process
response to drug
organic acid metabolic process
lipid metabolic process
small molecule metabolic process
cellular catabolic process