CYP2C8

Entrez Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].
UniProt Summary: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti- cancer drug paclitaxel (taxol). {ECO:0000269|PubMed:26427316, ECO:0000269|PubMed:7574697}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

caffeine oxidase activity
lipid hydroxylation
estrogen 16-alpha-hydroxylase activity
retinoic acid 4-hydroxylase activity
omega-hydroxylase P450 pathway
arachidonic acid epoxygenase activity
oxidative demethylation
epoxygenase P450 pathway
exogenous drug catabolic process
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
long-chain fatty acid biosynthetic process
retinoic acid metabolic process
estrogen metabolic process
monooxygenase activity
steroid hydroxylase activity
icosanoid biosynthetic process
arachidonic acid metabolic process
demethylation
fatty acid derivative biosynthetic process
retinoid metabolic process
unsaturated fatty acid metabolic process
diterpenoid metabolic process
icosanoid metabolic process
long-chain fatty acid metabolic process
fatty acid biosynthetic process
terpenoid metabolic process
cellular hormone metabolic process
xenobiotic metabolic process
iron ion binding
isoprenoid metabolic process
heme binding
drug catabolic process
fatty acid derivative metabolic process
monocarboxylic acid biosynthetic process
cellular response to xenobiotic stimulus
hormone metabolic process
lipid modification
steroid metabolic process
response to xenobiotic stimulus
carboxylic acid biosynthetic process