CYP2R1

Entrez Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in this gene has been associated with selective 25-hydroxyvitamin D deficiency. [provided by RefSeq, Jul 2008].
UniProt Summary: Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3). {ECO:0000269|PubMed:12867411, ECO:0000269|PubMed:15465040, ECO:0000269|PubMed:18511070}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

response to cesium ion
vitamin D3 25-hydroxylase activity
calcitriol biosynthetic process from calciol
vitamin D biosynthetic process
vitamin D3 metabolic process
cellular alcohol biosynthetic process
cellular alcohol metabolic process
fat-soluble vitamin biosynthetic process
vitamin D metabolic process
vitamin biosynthetic process
exogenous drug catabolic process
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
steroid hydroxylase activity
fat-soluble vitamin metabolic process
steroid hormone biosynthetic process
polyol biosynthetic process
hormone biosynthetic process
polyol metabolic process
alcohol biosynthetic process
vitamin metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
xenobiotic metabolic process
iron ion binding
heme binding
drug catabolic process
response to ionizing radiation
organic hydroxy compound biosynthetic process
cellular response to xenobiotic stimulus
hormone metabolic process
steroid metabolic process
response to xenobiotic stimulus
alcohol metabolic process
response to metal ion
response to radiation
organic hydroxy compound metabolic process
drug metabolic process
regulation of hormone levels
response to inorganic substance
lipid biosynthetic process